6S29
 
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6S1R
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6S1L
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6R8F
 | | Cryo-EM structure of the Human BRISC-SHMT2 complex | | Descriptor: | BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2), BRISC complex subunit Abraxas 2, ... | | Authors: | Walden, M, Hesketh, E, Tian, L, Ranson, N.A, Greenberg, R.A, Zeqiraj, E. | | Deposit date: | 2019-04-01 | | Release date: | 2019-06-05 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.
Nature, 570, 2019
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8Q6P
 | | X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
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8Q6O
 | | X. laevis CMG dimer bound to dimeric DONSON - without ATPase | | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | | Deposit date: | 2023-08-14 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation.
Mol.Cell, 83, 2023
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3OSK
 | | Crystal structure of human CTLA-4 apo homodimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, GLYCEROL | | Authors: | Yu, C, Sonnen, A.F.-P, Ikemizu, S, Stuart, D.I, Gilbert, R.J.C, Davis, S.J. | | Deposit date: | 2010-09-09 | | Release date: | 2010-12-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering
J.Biol.Chem., 286, 2011
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3JC7
 | | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | | Deposit date: | 2015-11-24 | | Release date: | 2016-02-10 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
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3JC6
 | | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | | Deposit date: | 2015-11-24 | | Release date: | 2016-02-10 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
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3JC5
 | | Structure of the eukaryotic replicative CMG helicase and pumpjack motion | | Descriptor: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | | Authors: | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | | Deposit date: | 2015-11-24 | | Release date: | 2016-02-10 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
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8THD
 | | Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to PCNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... | | Authors: | Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-07-14 | | Release date: | 2024-05-22 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure of the PCNA unloader Elg1-RFC.
Sci Adv, 10, 2024
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8THB
 | | Structure of the Saccharomyces cerevisiae PCNA clamp unloader Elg1-RFC complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... | | Authors: | Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-07-14 | | Release date: | 2024-05-22 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the PCNA unloader Elg1-RFC.
Sci Adv, 10, 2024
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8THC
 | | Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to a cracked PCNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... | | Authors: | Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-07-14 | | Release date: | 2024-05-22 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Structure of the PCNA unloader Elg1-RFC.
Sci Adv, 10, 2024
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8FS5
 | | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 3 (open 9-1-1 and stably bound chamber DNA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-01-09 | | Release date: | 2023-06-14 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
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8FS4
 | | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 2 (open 9-1-1 ring and flexibly bound chamber DNA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-01-09 | | Release date: | 2023-06-14 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
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8FS3
 | | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 1 (open 9-1-1 and shoulder bound DNA only) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-01-09 | | Release date: | 2023-06-14 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
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8FS8
 | | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 5-nt gapped DNA (9-1-1 encircling fully bound DNA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-01-09 | | Release date: | 2023-06-14 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
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8FS7
 | | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 5 (closed 9-1-1 and stably bound chamber DNA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-01-09 | | Release date: | 2023-06-14 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
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8FS6
 | | Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 4 (partially closed 9-1-1 and stably bound chamber DNA) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2023-01-09 | | Release date: | 2023-06-14 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
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7SH2
 | | Structure of the yeast Rad24-RFC loader bound to DNA and the open 9-1-1 clamp | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2021-10-07 | | Release date: | 2022-03-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
Nat.Struct.Mol.Biol., 29, 2022
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7SGZ
 | | Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... | | Authors: | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | | Deposit date: | 2021-10-07 | | Release date: | 2022-03-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
Nat.Struct.Mol.Biol., 29, 2022
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7KC0
 | | Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ... | | Authors: | Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E. | | Deposit date: | 2020-10-04 | | Release date: | 2020-12-02 | | Last modified: | 2020-12-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
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