6H4Y
| Crystal structure of human KDM4A in complex with compound 17e | Descriptor: | 8-[4-[2-[4-[4-(2-morpholin-4-ylethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Le Bihan, Y.V, van Montfort, R.L.M. | Deposit date: | 2018-07-23 | Release date: | 2019-06-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177, 2019
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6FXH
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2OG8
| crystal structure of aminoquinazoline 36 bound to Lck | Descriptor: | N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE, Proto-oncogene tyrosine-protein kinase LCK | Authors: | Huang, X. | Deposit date: | 2007-01-05 | Release date: | 2007-02-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity J.Med.Chem., 49, 2006
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4MNG
| Structure of the DP10.7 TCR with CD1d-sulfatide | Descriptor: | (15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | Authors: | Luoma, A.M, Adams, E.J. | Deposit date: | 2013-09-10 | Release date: | 2013-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.0058 Å) | Cite: | Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells. Immunity, 39, 2013
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4ET0
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4MQ7
| Structure of human CD1d-sulfatide | Descriptor: | (15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d, ... | Authors: | Luoma, A.M, Adams, E.J. | Deposit date: | 2013-09-15 | Release date: | 2013-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6032 Å) | Cite: | Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells. Immunity, 39, 2013
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1MYN
| SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES | Descriptor: | DROSOMYCIN | Authors: | Landon, C, Sodano, P, Hetru, C, Hoffmann, J.A, Ptak, M. | Deposit date: | 1996-12-26 | Release date: | 1997-12-31 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of drosomycin, the first inducible antifungal protein from insects. Protein Sci., 6, 1997
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4NDM
| Structure of the AB18.1 TCR | Descriptor: | Human nkt tcr alpha chain, T-cell gamma protein,T-cell receptor beta-2 chain C region | Authors: | Luoma, A.M, Adams, E.J. | Deposit date: | 2013-10-27 | Release date: | 2013-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.0065 Å) | Cite: | Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells. Immunity, 39, 2013
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4MNH
| Structure of the DP10.7 TCR | Descriptor: | Human nkt tcr alpha chain, T-cell receptor gamma chain V region PT-gamma-1/2, Human nkt tcr beta chain | Authors: | Luoma, A.M, Adams, E.J. | Deposit date: | 2013-09-10 | Release date: | 2013-12-18 | Last modified: | 2017-06-14 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells. Immunity, 39, 2013
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3ZWL
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3QQU
| Cocrystal structure of unphosphorylated igf with pyrimidine 8 | Descriptor: | Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Authors: | Huang, X. | Deposit date: | 2011-02-16 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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4H4B
| Human cytosolic 5'-nucleotidase II in complex with Anthraquinone-2,6- disulfonic acid | Descriptor: | 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | Authors: | Rhimi, M, Aghajari, N. | Deposit date: | 2012-09-17 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening. Biochem Pharmacol, 85, 2013
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3EYC
| New crystal structure of human tear lipocalin in complex with 1,4-butanediol in space group P21 | Descriptor: | 1,4-BUTANEDIOL, Lipocalin-1 | Authors: | Breustedt, D.A, Keil, L, Skerra, A. | Deposit date: | 2008-10-20 | Release date: | 2009-10-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity Acta Crystallogr.,Sect.D, 65, 2009
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1BKO
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1BSF
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1BKP
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3BYS
| co-crystal structure of Lck and aminopyrimidine amide 10b | Descriptor: | 4-methyl-N~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-N~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide, Proto-oncogene tyrosine-protein kinase LCK | Authors: | Huang, X. | Deposit date: | 2008-01-16 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J.Med.Chem., 51, 2008
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1MEY
| CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA | Descriptor: | CHLORIDE ION, CONSENSUS ZINC FINGER, DNA (5'-D(*AP*TP*GP*AP*GP*GP*CP*AP*GP*AP*AP*CP*T)-3'), ... | Authors: | Kim, C.A, Berg, J.M. | Deposit date: | 1996-09-27 | Release date: | 1997-03-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A 2.2 A Resolution Crystal Structure of a Designed Zinc Finger Protein Bound to DNA Nat.Struct.Biol., 3, 1996
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1D6B
| SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM | Descriptor: | DEFENSIN-LIKE PEPTIDE-2 | Authors: | Torres, A.M, De Plater, G.M, Doverskog, M, C Birinyi-Strachan, L, Nicholson, G.M, Gallagher, C.H, Kuchel, P.W. | Deposit date: | 1999-10-12 | Release date: | 2000-06-21 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold. Biochem.J., 348, 2000
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3BYU
| co-crystal structure of Lck and aminopyrimidine reverse amide 23 | Descriptor: | 2-methyl-N-{4-methyl-3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)carbamoyl]phenyl}-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase LCK | Authors: | Huang, X. | Deposit date: | 2008-01-16 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. J.Med.Chem., 51, 2008
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2CJI
| Crystal structure of a Human Factor Xa inhibitor complex | Descriptor: | 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE, ACTIVATED FACTOR XA HEAVY CHAIN, CALCIUM ION, ... | Authors: | Watson, N.S, Campbell, M, Chan, C, Convery, M.A, Hamblin, J.N, Kelly, H.A, King, N.P, Mason, A.M, Mitchell, C, Patel, V.K, Senger, S, Shah, G.P, Weston, H.E, Whitworth, C, Young, R.J. | Deposit date: | 2006-04-03 | Release date: | 2006-05-17 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Design and Synthesis of Orally Active Pyrrolidin-2-One-Based Factor Xa Inhibitors Bioorg.Med.Chem.Lett., 16, 2006
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1BSP
| THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS | Descriptor: | PHOSPHATE ION, THYMIDYLATE SYNTHASE A | Authors: | Stout, T.J, Schellenberger, U, Santi, D.V, Stroud, R.M. | Deposit date: | 1998-07-09 | Release date: | 1999-02-16 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry, 37, 1998
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3JXS
| Crystal structure of XG34, an evolved xyloglucan binding CBM | Descriptor: | ACETATE ION, CALCIUM ION, Xylanase | Authors: | Divne, C, Tan, T.-C, Brumer, H, Gullfot, F. | Deposit date: | 2009-09-21 | Release date: | 2009-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of XG-34, an evolved xyloglucan-specific carbohydrate-binding module. Proteins, 78, 2009
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3MBT
| Structure of monomeric Blc from E. coli | Descriptor: | Outer membrane lipoprotein blc | Authors: | Schiefner, A, Skerra, A. | Deposit date: | 2010-03-26 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and biochemical analyses reveal a monomeric state of the bacterial lipocalin Blc. Acta Crystallogr.,Sect.D, 66, 2010
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3KJM
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