1JJ9
| Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition | Descriptor: | 2-HYDROXY-5-[4-(2-HYDROXY-ETHYL)-PIPERIDIN-1-YL]-5-PHENYL-1H-PYRIMIDINE-4,6-DIONE, CALCIUM ION, Matrix Metalloproteinase 8, ... | Authors: | Brandstetter, H, Grams, F, Glitz, D, Lang, A, Huber, R, Bode, W, Krell, H.-W, Engh, R.A. | Deposit date: | 2001-07-04 | Release date: | 2001-08-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition. J.Biol.Chem., 276, 2001
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2DSP
| Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4 | Authors: | Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A. | Deposit date: | 2006-07-05 | Release date: | 2006-08-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2DSR
| Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4 | Authors: | Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A. | Deposit date: | 2006-07-05 | Release date: | 2006-08-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2FCB
| HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32) | Descriptor: | PROTEIN (FC GAMMA RIIB) | Authors: | Sondermann, P, Huber, R, Jacob, U. | Deposit date: | 1999-01-07 | Release date: | 2000-03-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution. EMBO J., 18, 1999
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1ONN
| IspC apo structure | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Authors: | Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | Deposit date: | 2003-02-28 | Release date: | 2003-03-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol
4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria
drug development. J.BIOL.CHEM., 278, 2003
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1WQJ
| Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs) | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor binding protein 4 | Authors: | Siwanowicz, I, Popowicz, G.M, Wisniewska, M, Huber, R, Kuenkele, K.P, Lang, K, Engh, R.A, Holak, T.A. | Deposit date: | 2004-09-29 | Release date: | 2005-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for the regulation of insulin-like growth factors by IGF binding proteins Structure, 13, 2005
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1OXD
| Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | Descriptor: | cyan fluorescent protein cfp | Authors: | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | Deposit date: | 2003-04-02 | Release date: | 2003-12-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins J.Mol.Biol., 328, 2003
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1OXE
| Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | Descriptor: | cyan fluorescent protein cfp | Authors: | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | Deposit date: | 2003-04-02 | Release date: | 2003-12-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins J.Mol.Biol., 328, 2003
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1OU5
| Crystal structure of human CCA-adding enzyme | Descriptor: | tRNA CCA-adding enzyme | Authors: | Augustin, M.A, Reichert, A.S, Betat, H, Huber, R, Moerl, M, Steegborn, C. | Deposit date: | 2003-03-24 | Release date: | 2003-05-06 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure of the Human CCA-adding Enzyme: Insights into Template-independent Polymerization J.Mol.Biol., 328, 2003
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1WYX
| The Crystal Structure of the p130Cas SH3 Domain at 1.1 A Resolution | Descriptor: | 1,2-ETHANEDIOL, CRK-associated substrate, MAGNESIUM ION | Authors: | Wisniewska, M, Bossenmaier, B, Georges, G, Hesse, F, Dangl, M, Kuenkele, K.P, Ioannidis, I, Huber, R, Engh, R.A. | Deposit date: | 2005-02-17 | Release date: | 2005-04-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity J.Mol.Biol., 347, 2005
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1PIX
| Crystal structure of the carboxyltransferase subunit of the bacterial ion pump glutaconyl-coenzyme A decarboxylase | Descriptor: | FORMIC ACID, Glutaconyl-CoA decarboxylase A subunit, SULFATE ION | Authors: | Wendt, K.S, Schall, I, Huber, R, Buckel, W, Jacob, U. | Deposit date: | 2003-05-30 | Release date: | 2003-08-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase Embo J., 22, 2003
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1C52
| THERMUS THERMOPHILUS CYTOCHROME-C552: A NEW HIGHLY THERMOSTABLE CYTOCHROME-C STRUCTURE OBTAINED BY MAD PHASING | Descriptor: | CYTOCHROME-C552, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Than, M.E, Hof, P, Huber, R, Bourenkov, G.P, Bartunik, H.D, Buse, G, Soulimane, T. | Deposit date: | 1997-06-23 | Release date: | 1998-06-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Thermus thermophilus cytochrome-c552: A new highly thermostable cytochrome-c structure obtained by MAD phasing. J.Mol.Biol., 271, 1997
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1C6O
| CRYSTAL STRUCTURE OF OXIDIZED CYTOCHROME C6 FROM THE GREEN ALGAE SCENEDESMUS OBLIQUUS | Descriptor: | CYTOCHROME C6, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Schnackenberg, J, Than, M.E, Mann, K, Wiegand, G, Huber, R, Reuter, W. | Deposit date: | 1999-04-07 | Release date: | 2000-04-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Amino acid sequence, crystallization and structure determination of reduced and oxidized cytochrome c6 from the green alga Scenedesmus obliquus. J.Mol.Biol., 290, 1999
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1PKQ
| Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex | Descriptor: | (8-18C5) chimeric Fab, heavy chain, light chain, ... | Authors: | Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U. | Deposit date: | 2003-06-06 | Release date: | 2003-07-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein Proc.Natl.Acad.Sci.USA, 100, 2003
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1C6R
| CRYSTAL STRUCTURE OF REDUCED CYTOCHROME C6 FROM THE GREEN ALGAE SCENEDESMUS OBLIQUUS | Descriptor: | CADMIUM ION, CYTOCHROME C6, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Schnackenberg, J, Than, M.E, Mann, K, Wiegand, G, Huber, R, Reuter, W. | Deposit date: | 1999-04-06 | Release date: | 2000-04-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Amino acid sequence, crystallization and structure determination of reduced and oxidized cytochrome c6 from the green alga Scenedesmus obliquus. J.Mol.Biol., 290, 1999
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1XRN
| Crystal structure of active site F1-mutant E213Q soaked with peptide Phe-Ala | Descriptor: | ALANINE, Proline iminopeptidase | Authors: | Goettig, P, Brandstetter, H, Groll, M, Goehring, W, Konarev, P.V, Svergun, D.I, Huber, R, Kim, J.-S. | Deposit date: | 2004-10-15 | Release date: | 2005-07-12 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum J.Biol.Chem., 280, 2005
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1CFR
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1CPC
| ISOLATION, CRYSTALLIZATION, CRYSTAL STRUCTURE ANALYSIS AND REFINEMENT OF CONSTITUTIVE C-PHYCOCYANIN FROM THE CHROMATICALLY ADAPTING CYANOBACTERIUM FREMYELLA DIPLOSIPHON AT 1.66 ANGSTROMS RESOLUTION | Descriptor: | C-PHYCOCYANIN (ALPHA SUBUNIT), C-PHYCOCYANIN (BETA SUBUNIT), PHYCOCYANOBILIN | Authors: | Duerring, M, Schmidt, G.B, Huber, R. | Deposit date: | 1990-10-11 | Release date: | 1993-01-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Isolation, crystallization, crystal structure analysis and refinement of constitutive C-phycocyanin from the chromatically adapting cyanobacterium Fremyella diplosiphon at 1.66 A resolution. J.Mol.Biol., 217, 1991
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1CDK
| CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C | Descriptor: | CAMP-DEPENDENT PROTEIN KINASE, MANGANESE (II) ION, MYRISTIC ACID, ... | Authors: | Bossemeyer, D, Engh, R.A, Kinzel, V, Ponstingl, H, Huber, R. | Deposit date: | 1994-07-04 | Release date: | 1995-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO J., 12, 1993
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1YOJ
| Crystal structure of Src kinase domain | Descriptor: | proto-oncogene tyrosine-protein kinase SRC | Authors: | Breitenlechner, C.B, Kairies, N.A, Honold, K, Scheiblich, S, Koll, H, Greiter, E, Koch, S, Schaefer, W, Huber, R, Engh, R.A. | Deposit date: | 2005-01-27 | Release date: | 2006-01-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structures of active SRC kinase domain complexes J.Mol.Biol., 353, 2005
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1AOC
| JAPANESE HORSESHOE CRAB COAGULOGEN | Descriptor: | COAGULOGEN, SULFATE ION | Authors: | Bergner, A, Oganessyan, V, Muta, T, Iwanaga, S, Typke, D, Huber, R, Bode, W. | Deposit date: | 1996-11-28 | Release date: | 1997-04-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor. EMBO J., 15, 1996
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1AUT
| Human activated protein C | Descriptor: | ACTIVATED PROTEIN C, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | Authors: | Mather, T, Oganessyan, V, Hof, P, Bode, W, Huber, R, Foundling, S, Esmon, C. | Deposit date: | 1996-06-08 | Release date: | 1997-08-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The 2.8 A crystal structure of Gla-domainless activated protein C. EMBO J., 15, 1996
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1P0K
| IPP:DMAPP isomerase type II apo structure | Descriptor: | Isopentenyl-diphosphate delta-isomerase, PHOSPHATE ION | Authors: | Steinbacher, S, Kaiser, J, Gerhardt, S, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | Deposit date: | 2003-04-10 | Release date: | 2003-06-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Bacillus subtilis J.Mol.Biol., 329, 2003
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1AVG
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1ONO
| IspC Mn2+ complex | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION | Authors: | Steinbacher, S, Kaiser, J, Eisenreich, W, Huber, R, Bacher, A, Rohdich, F. | Deposit date: | 2003-02-28 | Release date: | 2003-03-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol
4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria
drug development. J.BIOL.CHEM., 278, 2003
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