6CKL
 
 | N. meningitidis CMP-sialic acid synthetase in the presence of CMP and Neu5Ac2en | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, CHLORIDE ION, CITRATE ANION, ... | Authors: | Matthews, M.M, Fisher, A.J, Chen, X. | Deposit date: | 2018-02-28 | Release date: | 2019-03-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.684 Å) | Cite: | Catalytic Cycle ofNeisseria meningitidisCMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. Biochemistry, 2019
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8K4S
 
 | CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P | Descriptor: | (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yang, J, Fan, J.P, Lei, X.G. | Deposit date: | 2023-07-20 | Release date: | 2024-11-06 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell, 187, 2024
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6J7B
 
 | Crystal structure of VASH1-SVBP in complex with epoY | Descriptor: | N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Wang, N, Bao, H, Huang, H, Wu, B. | Deposit date: | 2019-01-17 | Release date: | 2019-06-19 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.618 Å) | Cite: | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
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6CKM
 
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7XPT
 
 | Crystal structrue of MtdL:GDP:Mn soaked with GDP-Glc | Descriptor: | GDP-ALPHA-D-GLUCOSE, MANGANESE (II) ION, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPR
 
 | Crystal structrue of SeMet-MtdL:GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPV
 
 | crysteal structure of MtdL-S228A-His soaked with GDP-Fucf and Mn | Descriptor: | MANGANESE (II) ION, Transglycosylse, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{S},3~{S},4~{S},5~{R})-3,4-bis(oxidanyl)-5-[(1~{S})-1-oxidanylethyl]oxolan-2-yl] hydrogen phosphate | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPU
 
 | crystal structure of MtdL-S228A-His soaked GDP-Fucp and Mn | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, MANGANESE (II) ION, ... | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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7XPS
 
 | Crystal structrue of MtdL:GDP:Mn | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, Transglycosylse | Authors: | Li, F.D, He, C. | Deposit date: | 2022-05-05 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding. J.Biol.Chem., 299, 2023
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8KEX
 
 | CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local | Descriptor: | (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid, Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4,Green fluorescent protein | Authors: | Yang, J, Fan, J.P, Lei, X.G. | Deposit date: | 2023-08-14 | Release date: | 2024-11-06 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell, 187, 2024
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6MZT
 
 | Solution structure of alpha-KTx-6.21 (UroTx) from Urodacus yaschenkoi | Descriptor: | Potassium channel toxin alpha-KTx 6.21 | Authors: | Chin, Y.K.-Y, Luna-Ramirez, K, Anangi, R, King, G.F. | Deposit date: | 2018-11-05 | Release date: | 2020-03-11 | Last modified: | 2024-10-23 | Method: | SOLUTION NMR | Cite: | Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem. Pharmacol., 174, 2020
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6CKK
 
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6EFC
 
 | Hsa Siglec + Unique domains (unliganded) | Descriptor: | CALCIUM ION, SODIUM ION, Streptococcal hemagglutinin | Authors: | Iverson, T.M. | Deposit date: | 2018-08-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun, 13, 2022
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6EFI
 
 | SK678 binding region (Siglec + Unique) | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, COBALT (II) ION, ... | Authors: | Iverson, T.M. | Deposit date: | 2018-08-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.715 Å) | Cite: | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun, 13, 2022
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6DWO
 
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6ER3
 
 | Ruminococcus gnavus IT-sialidase CBM40 bound to alpha2,3 sialyllactose | Descriptor: | BNR/Asp-box repeat protein, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose | Authors: | Owen, C.D, Tailford, L.E, Taylor, G.L, Juge, N. | Deposit date: | 2017-10-16 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun, 8, 2017
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6EF7
 
 | GspB Siglec domain | Descriptor: | CALCIUM ION, Platelet binding protein GspB | Authors: | Iverson, T.M. | Deposit date: | 2018-08-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun, 13, 2022
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6EFB
 
 | GspB Siglec domain | Descriptor: | CALCIUM ION, GLYCEROL, SK150 siglec + Unique, ... | Authors: | Iverson, T.M. | Deposit date: | 2018-08-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun, 13, 2022
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6EFA
 
 | GspB Siglec + Unique domains | Descriptor: | CALCIUM ION, Platelet binding protein GspB | Authors: | Iverson, T.M. | Deposit date: | 2018-08-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun, 13, 2022
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6EF9
 
 | GspB Siglec domain | Descriptor: | FORMIC ACID, Platelet binding protein GspB - Siglec domain, SODIUM ION | Authors: | Iverson, T.M. | Deposit date: | 2018-08-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation. Nat Commun, 13, 2022
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8WZ4
 
 | Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11 (localized refinement) | Descriptor: | 5B11 Fab Heavy Chain, 5B11 Fab Light Chain, RSV Fusion glycoprotein | Authors: | Liu, L, Sun, H, Sun, Y, Zheng, Q, Li, S, Zheng, Z, Xia, N. | Deposit date: | 2023-11-01 | Release date: | 2024-11-06 | Last modified: | 2025-06-04 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein. Nat Commun, 15, 2024
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8WZ3
 
 | Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5B11 Fab Heavy Chain, 5B11 Fab Light Chain, ... | Authors: | Liu, L, Sun, H, Sun, Y, Zheng, Q, Li, S, Zheng, Z, Xia, N. | Deposit date: | 2023-11-01 | Release date: | 2024-11-13 | Last modified: | 2025-06-04 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein. Nat Commun, 15, 2024
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8WZ5
 
 | Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 sc9-10 strain: B18537) in complex with humanized nAb 5B11 | Descriptor: | 5B11 Fab Heavy Chain, 5B11 Fab Light Chain, RSV Fusion glycoprotein | Authors: | Liu, L, Sun, H, Sun, Y, Zheng, Q, Li, S, Zheng, Z, Xia, N. | Deposit date: | 2023-11-01 | Release date: | 2024-11-13 | Last modified: | 2025-06-04 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein. Nat Commun, 15, 2024
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8WZE
 
 | Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 sc9-10 strain: B18537) in complex with humanized nAb 5B11 (localized refinement) | Descriptor: | 5B11 Fab Heavy Chain, 5B11 Fab Light Chain, RSV pre-fusion glycoprotein | Authors: | Liu, L, Sun, H, Sun, Y, Zheng, Q, Li, S, Zheng, Z, Xia, N. | Deposit date: | 2023-11-02 | Release date: | 2024-11-13 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein. Nat Commun, 15, 2024
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9BT9
 
 | Cryo-EM Structure of HKU1 spike D1 Domain (Active state, locally refined) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Jin, M, Rini, J.M. | Deposit date: | 2024-05-14 | Release date: | 2025-05-14 | Last modified: | 2025-05-21 | Method: | ELECTRON MICROSCOPY (2.11 Å) | Cite: | Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes. Nat Commun, 16, 2025
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