8GVC
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![BU of 8gvc by Molmil](/molmil-images/mine/8gvc) | The cryo-EM structure of hAE2 with bicarbonate | Descriptor: | Anion exchange protein 2, BICARBONATE ION | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-14 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVF
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![BU of 8gvf by Molmil](/molmil-images/mine/8gvf) | The outward-facing structure of hAE2 in basic pH | Descriptor: | Anion exchange protein 2 | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-15 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVA
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![BU of 8gva by Molmil](/molmil-images/mine/8gva) | The intermediate structure of hAE2 in basic pH | Descriptor: | Anion exchange protein 2 | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-14 | Release date: | 2023-04-12 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVE
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![BU of 8gve by Molmil](/molmil-images/mine/8gve) | The asymmetry structure of hAE2 | Descriptor: | Anion exchange protein 2 | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-15 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GV8
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![BU of 8gv8 by Molmil](/molmil-images/mine/8gv8) | The cryo-EM structure of hAE2 with DIDS | Descriptor: | 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid}, Anion exchange protein 2 | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-14 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVH
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![BU of 8gvh by Molmil](/molmil-images/mine/8gvh) | Human AE2 in acidic KNO3 | Descriptor: | Anion exchange protein 2, CHOLESTEROL HEMISUCCINATE | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-15 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GV9
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![BU of 8gv9 by Molmil](/molmil-images/mine/8gv9) | The cryo-EM structure of hAE2 with chloride ion | Descriptor: | Anion exchange protein 2, CHLORIDE ION | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-14 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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5C7M
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![BU of 5c7m by Molmil](/molmil-images/mine/5c7m) | CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT | Descriptor: | E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C | Authors: | Walker, J.R, Hu, J, Dong, A, Wernimont, A, Zhang, W, Sidhu, S, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2015-06-24 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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5C7J
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![BU of 5c7j by Molmil](/molmil-images/mine/5c7j) | CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT | Descriptor: | E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C | Authors: | Walker, J.R, Hu, J, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2015-06-24 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol.Cell, 62, 2016
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7UDK
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![BU of 7udk by Molmil](/molmil-images/mine/7udk) | Crystal structure of designed helical repeat protein RPB_LRP2_R4 bound to LRPx4 peptide | Descriptor: | 4xLRP, Designed helical repeat protein (DHR) RPB_LRP2_R4 | Authors: | Chang, Y, Redler, R.L, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-03-20 | Release date: | 2023-03-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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7UDL
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![BU of 7udl by Molmil](/molmil-images/mine/7udl) | Crystal structure of designed helical repeat protein RPB_PLP1_R6 bound to PLPx6 peptide | Descriptor: | 1,2-ETHANEDIOL, 6xPLP Peptide, Designed helical repeat protein (DHR) RPB_PLP1_R6 | Authors: | Chang, Y, Redler, R.L, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-03-20 | Release date: | 2023-03-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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7UDN
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![BU of 7udn by Molmil](/molmil-images/mine/7udn) | |
7UDM
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![BU of 7udm by Molmil](/molmil-images/mine/7udm) | Crystal structure of designed helical repeat protein RPB_PLP1_R6 in alternative conformation 1 (with peptide) | Descriptor: | 6xPLP, Designed helical repeat protein (DHR) RPB_PLP1_R6 | Authors: | Chang, Y, Redler, R.L, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-03-20 | Release date: | 2023-03-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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7UDO
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![BU of 7udo by Molmil](/molmil-images/mine/7udo) | Crystal structure of designed helical repeat protein RPB_LRP2_R4 (proteolysis fragment?), forming pseudopolymeric filaments | Descriptor: | 1,2-ETHANEDIOL, Designed helical repeat protein (DHR) RPB_LRP2_R4, PHOSPHATE ION | Authors: | Redler, R.L, Chang, Y, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-03-20 | Release date: | 2023-03-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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7UDJ
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![BU of 7udj by Molmil](/molmil-images/mine/7udj) | Crystal structure of designed helical repeat protein RPB_PEW3_R4 bound to PAWx4 peptide | Descriptor: | 4xPAW peptide, De novo designed helical repeat protein RPB_PEW3_R4 | Authors: | Redler, R.L, Chang, Y, Bhabha, G, Ekiert, D. | Deposit date: | 2022-03-20 | Release date: | 2023-03-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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7UE2
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![BU of 7ue2 by Molmil](/molmil-images/mine/7ue2) | |
8IP4
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![BU of 8ip4 by Molmil](/molmil-images/mine/8ip4) | Cryo-EM structure of hMRS-highEDTA | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | Deposit date: | 2023-03-14 | Release date: | 2023-06-14 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel. Nat Commun, 14, 2023
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8IP5
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![BU of 8ip5 by Molmil](/molmil-images/mine/8ip5) | Cryo-EM structure of hMRS2-lowEDTA | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | Deposit date: | 2023-03-14 | Release date: | 2023-06-14 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel. Nat Commun, 14, 2023
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8IP6
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![BU of 8ip6 by Molmil](/molmil-images/mine/8ip6) | Cryo-EM structure of hMRS2-rest | Descriptor: | CHLORIDE ION, Magnesium transporter MRS2 homolog, mitochondrial | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | Deposit date: | 2023-03-14 | Release date: | 2023-06-14 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel. Nat Commun, 14, 2023
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8IP3
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![BU of 8ip3 by Molmil](/molmil-images/mine/8ip3) | Cryo-EM structure of hMRS2-Mg | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Magnesium transporter MRS2 homolog, ... | Authors: | Li, M, Li, Y, Yang, X, Shen, Y.Q. | Deposit date: | 2023-03-14 | Release date: | 2023-06-14 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Molecular basis of Mg 2+ permeation through the human mitochondrial Mrs2 channel. Nat Commun, 14, 2023
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6IJ7
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![BU of 6ij7 by Molmil](/molmil-images/mine/6ij7) | Crystal Structure of Arabidopsis thaliana UGT89C1 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Rhamnosyltransferase protein | Authors: | Zong, G, Wang, X. | Deposit date: | 2018-10-09 | Release date: | 2019-09-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP-beta-l-rhamnose and rhamnosylation mechanism. Plant J., 99, 2019
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8I91
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![BU of 8i91 by Molmil](/molmil-images/mine/8i91) | ACE2-SIT1 complex bound with proline | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H. | Deposit date: | 2023-02-06 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1. Cell Discov, 9, 2023
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8I93
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![BU of 8i93 by Molmil](/molmil-images/mine/8i93) | ACE2-B0AT1 complex bound with methionine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H. | Deposit date: | 2023-02-06 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1. Cell Discov, 9, 2023
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8I92
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![BU of 8i92 by Molmil](/molmil-images/mine/8i92) | ACE2-B0AT1 complex bound with glutamine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H. | Deposit date: | 2023-02-06 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1. Cell Discov, 9, 2023
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6ONY
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![BU of 6ony by Molmil](/molmil-images/mine/6ony) | BRD2_Bromodomain1 complex with inhibitor 744 | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 2, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide | Authors: | Longenecker, K.L, Bigelow, L. | Deposit date: | 2019-04-22 | Release date: | 2020-01-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature, 578, 2020
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