2AW9
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2APQ
| Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop. | Descriptor: | PHOSPHATE ION, Ribonuclease | Authors: | Sambashivan, S, Liu, Y, Sawaya, M.R, Gingery, M, Eisenberg, D. | Deposit date: | 2005-08-16 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature, 437, 2005
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2EWH
| Carboxysome protein CsoS1A from Halothiobacillus neapolitanus | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Major carboxysome shell protein 1A | Authors: | Tsai, Y, Sawaya, M.R, Kerfeld, C.A, Yeates, T.O. | Deposit date: | 2005-11-03 | Release date: | 2006-11-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Analysis of CsoS1A and the Protein Shell of the Halothiobacillus neapolitanus Carboxysome. Plos Biol., 5, 2007
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4IVJ
| Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, I222 form | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2013-01-23 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (7.351 Å) | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. J.Am.Chem.Soc., 135, 2013
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8T0B
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8T1N
| Micro-ED Structure of a Novel Domain of Unknown Function Solved with AlphaFold | Descriptor: | DUF1842 domain-containing protein | Authors: | Miller, J.E, Cascio, D, Sawaya, M.R, Cannon, K.A, Rodriguez, J.A, Yeates, T.O. | Deposit date: | 2023-06-02 | Release date: | 2024-01-17 | Last modified: | 2024-04-10 | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | Cite: | AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. Acta Crystallogr D Struct Biol, 80, 2024
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4LFD
| Staphylococcus aureus sortase B-substrate complex | Descriptor: | (CBZ)NPQ(B27) PEPTIDE, SULFATE ION, Sortase B | Authors: | Jacobitz, A.W, Sawaya, M.R, Yi, S.W, Amer, B.R, Huang, G.L, Nguyen, A.V, Jung, M.E, Clubb, R.T. | Deposit date: | 2013-06-26 | Release date: | 2014-02-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural and Computational Studies of the Staphylococcus aureus Sortase B-Substrate Complex Reveal a Substrate-stabilized Oxyanion Hole. J.Biol.Chem., 289, 2014
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8SPA
| Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment | Descriptor: | Cytoplasmic polyadenylation element-binding protein 3 | Authors: | Flores, M.D, Sawaya, M.R, Boyer, D.R, Zink, S, Fioriti, L, Rodriguez, J.A. | Deposit date: | 2023-05-02 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation To Be Published
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8UMP
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8UF0
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8TEQ
| Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber | Descriptor: | TRK-fused gene protein Low Complexity Domain G269V mutant | Authors: | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | Deposit date: | 2023-07-06 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2, 2023
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8TER
| Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber | Descriptor: | TRK-fused gene protein Low Complexity Domain P285L mutant | Authors: | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | Deposit date: | 2023-07-06 | Release date: | 2023-12-20 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2, 2023
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4LCL
| Simvastatin Synthase (LOVD), from Aspergillus Terreus, LovD6 mutant (simh6208) | Descriptor: | ISOPROPYL ALCOHOL, Transesterase | Authors: | Gao, X, Sawaya, M.R, Yeates, T.O, Tang, Y. | Deposit date: | 2013-06-21 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The role of distant mutations and allosteric regulation on LovD active site dynamics. Nat.Chem.Biol., 10, 2014
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4LCM
| Simvastatin Synthase (LOVD), from Aspergillus Terreus, LovD9 mutant (simh9014) | Descriptor: | Transesterase | Authors: | Gao, X, Sawaya, M.R, Yeates, T.O, Tang, Y. | Deposit date: | 2013-06-21 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | The role of distant mutations and allosteric regulation on LovD active site dynamics. Nat.Chem.Biol., 10, 2014
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8UI2
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8UKM
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8UMR
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8UN1
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8T1M
| Novel Domain of Unknown Function Solved with AlphaFold | Descriptor: | DUF1842 domain-containing protein | Authors: | Miller, J.E, Agdanowski, M.P, Cascio, D, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-06-02 | Release date: | 2024-01-17 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. Acta Crystallogr D Struct Biol, 80, 2024
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4M5T
| Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide | Descriptor: | Alpha-crystallin B chain, SULFATE ION | Authors: | Laganowsky, A, Cascio, D, Hochberg, G, Sawaya, M.R, Benesch, J.L.P, Robinson, C.V, Eisenberg, D. | Deposit date: | 2013-08-08 | Release date: | 2014-04-09 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity. Proc.Natl.Acad.Sci.USA, 111, 2014
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4K2X
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4MJH
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4M5S
| Human alphaB crystallin core domain in complex with C-terminal peptide | Descriptor: | Alpha-crystallin B chain, SUCCINIC ACID | Authors: | Laganowsky, A, Cascio, D, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2013-08-08 | Release date: | 2014-04-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity. Proc.Natl.Acad.Sci.USA, 111, 2014
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4IQ4
| Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P21212 form | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2013-01-10 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.495 Å) | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. J.Am.Chem.Soc., 135, 2013
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4ITV
| Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P212121 form | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2013-01-18 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.598 Å) | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. J.Am.Chem.Soc., 135, 2013
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