4F8H
 
 | | X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel | | Descriptor: | (R)-ketamine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Proton-gated ion channel, ... | | Authors: | Pan, J.J, Chen, Q, Willenbring, D, Kong, X.P, Cohen, A, Xu, Y, Tang, P. | | Deposit date: | 2012-05-17 | | Release date: | 2012-08-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine.
Structure, 20, 2012
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5DX4
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand | | Descriptor: | 1,2-ETHANEDIOL, 5-bromo-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-2-methoxybenzenesulfonamide, Bromodomain-containing protein 4, ... | | Authors: | Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. | | Deposit date: | 2015-09-23 | | Release date: | 2016-01-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
J.Med.Chem., 59, 2016
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7Y8R
 | | The nucleosome-bound human PBAF complex | | Descriptor: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | | Authors: | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | | Deposit date: | 2022-06-24 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of nucleosome-bound human PBAF complex.
Nat Commun, 13, 2022
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3U0J
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3U9G
 | | Crystal structure of the Zinc finger antiviral protein | | Descriptor: | ZINC ION, Zinc finger CCCH-type antiviral protein 1 | | Authors: | Chen, S, Xu, Y, Zhang, K, Wang, X, Sun, J, Gao, G, Liu, Y. | | Deposit date: | 2011-10-18 | | Release date: | 2012-03-14 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA.
Nat.Struct.Mol.Biol., 19, 2012
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1QCQ
 | | UBIQUITIN CONJUGATING ENZYME | | Descriptor: | PROTEIN (UBIQUITIN CONJUGATING ENZYME) | | Authors: | Cook, W.J, Jeffrey, L.C, Xu, Y, Chau, V. | | Deposit date: | 1999-05-10 | | Release date: | 1999-05-17 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: crystal structure of yeast Ubc4.
Biochemistry, 32, 1993
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1R19
 | | Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (Apo structure) | | Descriptor: | fibrinogen-binding protein SdrG | | Authors: | Ponnuraj, K, Bowden, M.G, Davis, S, Gurusiddappa, S, Moore, D, Choe, D, Xu, Y, Hook, M, Narayana, S.V.L. | | Deposit date: | 2003-09-23 | | Release date: | 2003-10-28 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | A "dock, lock and latch" Structural Model for a Staphylococcal Adhesin Binding to Fibrinogen
Cell(Cambridge,Mass.), 115, 2003
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1RTK
 | | Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid | | Descriptor: | 4-carbamimidamidobenzoic acid, Complement factor B Bb fragment, IODIDE ION, ... | | Authors: | Ponnuraj, K, Xu, Y, Macon, K, Moore, D, Volanakis, J.E, Narayana, S.V. | | Deposit date: | 2003-12-10 | | Release date: | 2004-12-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol.Cell, 14, 2004
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1R17
 | | Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex) | | Descriptor: | CALCIUM ION, fibrinogen-binding protein SdrG, fibrinopeptide B | | Authors: | Ponnuraj, K, Bowden, M.G, Davis, S, Gurusiddappa, S, Moore, D, Choe, D, Xu, Y, Hook, M, Narayana, S.V.L. | | Deposit date: | 2003-09-23 | | Release date: | 2003-10-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | A "dock, lock and latch" Structural Model for a Staphylococcal Adhesin Binding to Fibrinogen
Cell(Cambridge,Mass.), 115, 2003
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1RRK
 | | Crystal Structure Analysis of the Bb segment of Factor B | | Descriptor: | COBALT (II) ION, Complement factor B, IODIDE ION, ... | | Authors: | Ponnuraj, K, Xu, Y, Macon, K, Moore, D, Volanakis, J.E, Narayana, S.V. | | Deposit date: | 2003-12-08 | | Release date: | 2004-12-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol.Cell, 14, 2004
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1RS0
 | | Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP) | | Descriptor: | Complement factor B, DIISOPROPYL PHOSPHONATE, IODIDE ION, ... | | Authors: | Ponnuraj, K, Xu, Y, Macon, K, Moore, D, Volanakis, J.E, Narayana, S.V. | | Deposit date: | 2003-12-09 | | Release date: | 2004-12-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol.Cell, 14, 2004
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3WLF
 | | Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with (R)-1-phenyl-1,2-ethanediol | | Descriptor: | (1R)-1-phenylethane-1,2-diol, (R)-specific carbonyl reductase, ZINC ION | | Authors: | Wang, S.S, Nie, Y, Xu, Y, Zhang, R.Z, Huang, C.H, Chan, H.C, Guo, R.T, Xiao, R. | | Deposit date: | 2013-11-09 | | Release date: | 2014-07-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase
Chem.Commun.(Camb.), 50, 2014
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3WLE
 | | Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with NAD | | Descriptor: | (R)-specific carbonyl reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | | Authors: | Wang, S.S, Nie, Y, Xu, Y, Zhang, R.Z, Huang, C.H, Chan, H.C, Guo, R.T, Xiao, R. | | Deposit date: | 2013-11-08 | | Release date: | 2014-07-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.164 Å) | | Cite: | Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase
Chem.Commun.(Camb.), 50, 2014
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3WNQ
 | | Crystal structure of (R)-carbonyl reductase H49A mutant from Candida Parapsilosis in complex with 2-hydroxyacetophenone | | Descriptor: | (R)-specific carbonyl reductase, 2-hydroxy-1-phenylethanone, ZINC ION | | Authors: | Wang, S.S, Nie, Y, Xu, Y, Zhang, R.Z, Huang, C.H, Chan, H.C, Guo, R.T, Ko, T.P, Xiao, R. | | Deposit date: | 2013-12-15 | | Release date: | 2014-07-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase
Chem.Commun.(Camb.), 50, 2014
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1TF7
 | | Crystal Structure of Circadian Clock Protein KaiC | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, KaiC | | Authors: | Pattanayek, R, Wang, J, Mori, T, Xu, Y, Johnson, C.H, Egli, M. | | Deposit date: | 2004-05-26 | | Release date: | 2004-08-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Visualizing a Circadian Clock Protein; Crystal Structure of KaiC and Functional Insights
Mol.Cell, 15, 2004
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4RAP
 | | Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407 | | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, Glycosyltransferase TibC | | Authors: | Yao, Q, Lu, Q, Xu, Y, Shao, F. | | Deposit date: | 2014-09-10 | | Release date: | 2014-10-29 | | Method: | X-RAY DIFFRACTION (2.881 Å) | | Cite: | A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family.
Elife, 3, 2014
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5D9Y
 | | Crystal structure of TET2-5fC complex | | Descriptor: | DNA (5'-D(*AP*CP*TP*GP*TP*(5FC)P*GP*AP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*TP*CP*GP*AP*CP*AP*GP*T)-3'), FE (III) ION, ... | | Authors: | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | | Deposit date: | 2015-08-19 | | Release date: | 2015-11-04 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.971 Å) | | Cite: | Structural insight into substrate preference for TET-mediated oxidation.
Nature, 527, 2015
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3R7W
 | | Crystal Structure of Gtr1p-Gtr2p complex | | Descriptor: | GTP-binding protein GTR1, GTP-binding protein GTR2, MAGNESIUM ION, ... | | Authors: | Gong, R, Li, L, Liu, Y, Wang, P, Yang, H, Wang, L, Cheng, J, Guan, K.L, Xu, Y. | | Deposit date: | 2011-03-23 | | Release date: | 2011-08-24 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (2.773 Å) | | Cite: | Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
Genes Dev., 25, 2011
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5DEU
 | | Crystal structure of TET2-5hmC complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, DNA (5'-D(*AP*CP*CP*AP*CP*(5HC)P*GP*GP*TP*GP*GP*T)-3'), ... | | Authors: | Hu, L, Cheng, J, Rao, Q, Li, Z, Li, J, Xu, Y. | | Deposit date: | 2015-08-26 | | Release date: | 2015-11-04 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.801 Å) | | Cite: | Structural insight into substrate preference for TET-mediated oxidation.
Nature, 527, 2015
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3SHB
 | | Crystal Structure of PHD Domain of UHRF1 | | Descriptor: | E3 ubiquitin-protein ligase UHRF1, Histone H3 peptide, ZINC ION | | Authors: | Hu, L, Li, Z, Wang, P, Lin, Y, Xu, Y. | | Deposit date: | 2011-06-16 | | Release date: | 2011-08-24 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.
Cell Res., 2011
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2M6B
 | | Structure of full-length transmembrane domains of human glycine receptor alpha1 monomer subunit | | Descriptor: | Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit | | Authors: | Mowrey, D, Cui, T, Jia, Y, Ma, D, Makhov, A.M, Zhang, P, Tang, P, Xu, Y. | | Deposit date: | 2013-03-28 | | Release date: | 2013-09-04 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Open-Channel Structures of the Human Glycine Receptor alpha 1 Full-Length Transmembrane Domain.
Structure, 21, 2013
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2M6I
 | | Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit | | Descriptor: | Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit | | Authors: | Mowrey, D, Cui, T, Jia, Y, Ma, D, Makhov, A.M, Zhang, P, Tang, P, Xu, Y. | | Deposit date: | 2013-03-29 | | Release date: | 2013-09-04 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Open-Channel Structures of the Human Glycine Receptor alpha 1 Full-Length Transmembrane Domain.
Structure, 21, 2013
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8W8E
 | | human co-transcriptional RNA capping enzyme RNGTT | | Descriptor: | DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ... | | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | | Deposit date: | 2023-09-02 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Strcutures of co-transcriptional RNA capping enzymes on paused transcription complex
To Be Published
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8W8F
 | | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | | Descriptor: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... | | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | | Deposit date: | 2023-09-02 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Strcutures of co-transcriptional RNA capping enzymes on paused transcription complex
To Be Published
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5H1B
 | | Human RAD51 presynaptic complex | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, MAGNESIUM ION, ... | | Authors: | Xu, J, Zhao, L, Xu, Y, Zhao, W, Sung, P, Wang, H.W. | | Deposit date: | 2016-10-08 | | Release date: | 2016-12-21 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange
Nat. Struct. Mol. Biol., 24, 2017
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