6G3B
 
 | AvaII restriction endonuclease in complex with an RNA/DNA hybrid | Descriptor: | DNA (5'-D(*CP*CP*AP*TP*GP*GP*TP*CP*CP*TP*A)-3'), RNA (5'-R(P*GP*UP*AP*GP*GP*AP*CP*CP*AP*UP*G)-3'), Type II site-specific deoxyribonuclease | Authors: | Kisiala, M, Kowalska, M, Czapinska, H, Bochtler, M. | Deposit date: | 2018-03-24 | Release date: | 2019-04-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation Nucleic Acids Res., 2020
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2RMX
 
 | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A | Descriptor: | NKG2-A/NKG2-B type II integral membrane protein, Tyrosine-protein phosphatase non-receptor type 6 | Authors: | Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-11-30 | Release date: | 2008-12-02 | Last modified: | 2024-11-20 | Method: | SOLUTION NMR | Cite: | Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1 To be Published
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8IVR
 
 | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease | Descriptor: | (2R,3S)-2-methyl-3-(4-methylphenyl)-3-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoylamino]propanoic acid, Kelch-like ECH-associated protein 1, SULFATE ION | Authors: | Nomura, A, Yamaguchi, K, Adachi, T. | Deposit date: | 2023-03-28 | Release date: | 2023-06-14 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor. Acs Med.Chem.Lett., 14, 2023
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8IXS
 
 | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1/Nrf2 PPI Inhibitor for Treatment of Chronic Kidney Disease | Descriptor: | (2R,3S)-3-[[(2S)-2-fluoranyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoyl]amino]-2-methyl-3-(4-methylphenyl)propanoic acid, Kelch-like ECH-associated protein 1, SULFATE ION | Authors: | Nomura, A, Yamaguchi, K, Adachi, T. | Deposit date: | 2023-04-03 | Release date: | 2023-06-14 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor. Acs Med.Chem.Lett., 14, 2023
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2COM
 
 | The solution structure of the SWIRM domain of human LSD1 | Descriptor: | Lysine-specific histone demethylase 1 | Authors: | Tochio, N, Umehara, T, Koshiba, S, Inoue, M, Tanaka, A, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-18 | Release date: | 2005-11-18 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the SWIRM domain of human histone demethylase LSD1 Structure, 14, 2006
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1DHY
 
 | KKS102 BPHC ENZYME | Descriptor: | 2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE, FE (III) ION | Authors: | Senda, T, Sugiyama, K, Narita, H, Mitsui, Y. | Deposit date: | 1995-07-07 | Release date: | 1995-10-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three-dimensional structures of free form and two substrate complexes of an extradiol ring-cleavage type dioxygenase, the BphC enzyme from Pseudomonas sp. strain KKS102. J.Mol.Biol., 255, 1996
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4YH8
 
 | Structure of yeast U2AF complex | Descriptor: | Splicing factor U2AF 23 kDa subunit, Splicing factor U2AF 59 kDa subunit, ZINC ION | Authors: | Yoshida, H, Park, S.Y, Urano, T, Obayashi, E. | Deposit date: | 2015-02-27 | Release date: | 2015-08-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit. Genes Dev., 29, 2015
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2RVM
 
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2RVN
 
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2RVL
 
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3WKM
 
 | The periplasmic PDZ tandem fragment of the RseP homologue from Aquifex aeolicus in complex with the Fab fragment | Descriptor: | MOUSE IGG1-KAPPA FAB (HEAVY CHAIN), MOUSE IGG1-KAPPA FAB (LIGHT CHAIN), Putative zinc metalloprotease aq_1964 | Authors: | Nogi, T, Tabata, S, Tamura-kawakami, K, Takagi, J. | Deposit date: | 2013-10-28 | Release date: | 2013-12-18 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Structure-Based Model of Substrate Discrimination by a Noncanonical PDZ Tandem in the Intramembrane-Cleaving Protease RseP Structure, 22, 2013
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5YFI
 
 | Crystal structure of the anti-human prostaglandin E receptor EP4 antibody Fab fragment | Descriptor: | Heavy chain of Fab fragment, Light chain of Fab fragment, ZINC ION | Authors: | Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T. | Deposit date: | 2017-09-21 | Release date: | 2018-12-05 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.848 Å) | Cite: | Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15, 2019
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5YHL
 
 | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative | Descriptor: | 4-[2-[[(2R)-2-(4-bromanylnaphthalen-1-yl)propanoyl]amino]-4-cyano-phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ... | Authors: | Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T. | Deposit date: | 2017-09-28 | Release date: | 2018-12-05 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15, 2019
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5YWY
 
 | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208 | Descriptor: | 4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ... | Authors: | Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T. | Deposit date: | 2017-11-30 | Release date: | 2018-12-05 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. Nat. Chem. Biol., 15, 2019
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5Y25
 
 | EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062 | Descriptor: | (2R)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide, Epidermal growth factor receptor | Authors: | Shiroishi, M, Abe, Y, Caaveiro, J.M.M, Sakamoto, S, Morimoto, S, Fuchida, H, Shindo, N, Ojida, A. | Deposit date: | 2017-07-24 | Release date: | 2018-07-25 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (3.102 Å) | Cite: | Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat.Chem.Biol., 15, 2019
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4XZG
 
 | Crystal structure of HIRAN domain of human HLTF | Descriptor: | Helicase-like transcription factor | Authors: | Ikegaya, Y, Hara, K, Hashimoto, H. | Deposit date: | 2015-02-04 | Release date: | 2015-04-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance J.Biol.Chem., 290, 2015
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4XZF
 
 | Crystal structure of HIRAN domain of human HLTF in complex with DNA | Descriptor: | (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor | Authors: | Hishiki, A, Hashimoto, H. | Deposit date: | 2015-02-04 | Release date: | 2015-04-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance J.Biol.Chem., 290, 2015
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2LC2
 
 | Solution structure of the RXLR effector P. capsici AVR3a4 | Descriptor: | AVR3a4 | Authors: | Li, H, Koshiba, S, Yaeno, T, Sato, M, Watanabe, S, Harada, T, Shirasu, K, Kigawa, T. | Deposit date: | 2011-04-12 | Release date: | 2011-08-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A PIP-binding interface in the oomycete RXLR effector AVR3A is required for its accumulation in host cells to modulate plant immunity To be Published
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5X2D
 
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5X2E
 
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1IQQ
 
 | Crystal Structure of Japanese pear S3-RNase | Descriptor: | S3-RNase, beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Matsuura, T, Sakai, H, Norioka, S. | Deposit date: | 2001-07-25 | Release date: | 2001-11-07 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure at 1.5-A resolution of Pyrus pyrifolia pistil ribonuclease responsible for gametophytic self-incompatibility. J.Biol.Chem., 276, 2001
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6A88
 
 | Crystal Structure of T. gondii prolyl tRNA synthetase with Febrifugine and ATP Analog | Descriptor: | 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Kumari, S, Mishra, S, Yogavel, M, Sharma, A. | Deposit date: | 2018-07-06 | Release date: | 2019-10-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | Conformational heterogeneity in apo and drug-bound structures of Toxoplasma gondii prolyl-tRNA synthetase. Acta Crystallogr.,Sect.F, 75, 2019
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6AA0
 
 | Crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in Apo Form | Descriptor: | GLYCEROL, Prolyl-tRNA synthetase (ProRS) | Authors: | Mishra, S, Kumari, S, Sharma, A, Yogavel, M. | Deposit date: | 2018-07-16 | Release date: | 2019-10-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Conformational heterogeneity in apo and drug-bound structures of Toxoplasma gondii prolyl-tRNA synthetase. Acta Crystallogr.,Sect.F, 75, 2019
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1DLF
 
 | HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FV FRAGMENT FROM AN ANTI-DANSYL SWITCH VARIANT ANTIBODY IGG2A(S) CRYSTALLIZED AT PH 5.25 | Descriptor: | ANTI-DANSYL IMMUNOGLOBULIN IGG2A(S), SULFATE ION | Authors: | Nakasako, M, Takahashi, H, Shimada, I, Arata, Y. | Deposit date: | 1998-07-14 | Release date: | 1999-07-26 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The pH-dependent structural variation of complementarity-determining region H3 in the crystal structures of the Fv fragment from an anti-dansyl monoclonal antibody. J.Mol.Biol., 291, 1999
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1BFN
 
 | BETA-AMYLASE/BETA-CYCLODEXTRIN COMPLEX | Descriptor: | BETA-AMYLASE, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), SULFATE ION | Authors: | Adachi, M, Mikami, B, Katsube, T, Utsumi, S. | Deposit date: | 1998-05-22 | Release date: | 1998-10-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal structure of recombinant soybean beta-amylase complexed with beta-cyclodextrin. J.Biol.Chem., 273, 1998
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