3VHD
 
 | | Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840 | | Descriptor: | 4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1(2,6)]docosa-1(20),2,4,6(22),17(21),18-hexaene-10,16-dione, Heat shock protein HSP 90-alpha | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-08-24 | | Release date: | 2012-07-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
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6E56
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5IH9
 | | MELK in complex with NVS-MELK8A | | Descriptor: | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine, Maternal embryonic leucine zipper kinase | | Authors: | Sprague, E.R, Puleo, D.E. | | Deposit date: | 2016-02-29 | | Release date: | 2016-06-01 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
J.Med.Chem., 59, 2016
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5IH8
 | | MELK in complex with NVS-MELK1 | | Descriptor: | Maternal embryonic leucine zipper kinase, N-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1H-pyrazol-1-yl]benzamide | | Authors: | Sprague, E.R, Puleo, D.E. | | Deposit date: | 2016-02-29 | | Release date: | 2016-06-01 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
J.Med.Chem., 59, 2016
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1WWQ
 | | Solution Structure of Mouse ER | | Descriptor: | Enhancer of rudimentary homolog | | Authors: | Li, H, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-01-12 | | Release date: | 2006-01-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold
J.Biomol.Nmr, 32, 2005
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3NDR
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5X9C
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6LA0
 | | Crystal structure of AoRut | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoside hydrolase family 5 | | Authors: | Koseki, T, Makabe, K. | | Deposit date: | 2019-11-11 | | Release date: | 2020-11-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Aspergillus oryzae Rutinosidase: Biochemical and Structural Investigation.
Appl.Environ.Microbiol., 87, 2021
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2RLT
 | | phosphorylated CPI-17 (22-120) | | Descriptor: | Protein phosphatase 1 regulatory subunit 14A | | Authors: | Eto, M. | | Deposit date: | 2007-08-11 | | Release date: | 2008-07-15 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor.
Structure, 15, 2007
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5YS2
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5YSL
 | | Crystal structure of antibody 1H1 Fab | | Descriptor: | 1H1 heavy chain, 1H1 light chain | | Authors: | Hu, X.L, Yang, F.L. | | Deposit date: | 2017-11-14 | | Release date: | 2017-12-27 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design.
PLoS Pathog., 13, 2017
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5ZQ1
 | | Crystal structure of spRlmCD with U1939loop RNA at 3.10 angstrom | | Descriptor: | RNA (5'-R(*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | | Authors: | Yu, H.L, Jiang, Y.Y. | | Deposit date: | 2018-04-17 | | Release date: | 2018-10-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
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5ZQ0
 | | Crystal structure of spRlmCD with U747loop RNA | | Descriptor: | RNA (5'-R(*GP*UP*(MUM)P*GP*AP*AP*AP*A)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | | Authors: | Jiang, Y.Y, Yu, H.L. | | Deposit date: | 2018-04-17 | | Release date: | 2018-10-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
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5XJ2
 | | Structure of spRlmCD with U747 RNA | | Descriptor: | RNA (5'-R(*GP*GP*CP*AP*CP*GP*UP*GP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029, ... | | Authors: | Jiang, Y, Gong, Q. | | Deposit date: | 2017-04-28 | | Release date: | 2017-11-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.84 Å) | | Cite: | Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
PLoS ONE, 12, 2017
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5ZQ8
 | | Crystal structure of spRlmCD with U747 stemloop RNA | | Descriptor: | NICKEL (II) ION, RNA (5'-R(*CP*CP*GP*UP*(MUM)P*GP*AP*AP*AP*AP*GP*G)-3'), S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Jiang, Y.Y, Yu, H.L. | | Deposit date: | 2018-04-17 | | Release date: | 2018-10-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
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5XJ1
 | | Crystal structure of spRlmCD | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Jiang, Y, Gong, Q. | | Deposit date: | 2017-04-28 | | Release date: | 2017-11-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.753 Å) | | Cite: | Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
PLoS ONE, 12, 2017
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5XJ3
 | | Complex structure of ipilimumab-scFv and CTLA-4 | | Descriptor: | Cytotoxic T-lymphocyte protein 4, ipilimumab-VH, ipilimumab-VL | | Authors: | He, M, Chai, Y, Qi, J, Tong, Z, Tan, S, Gao, G.F. | | Deposit date: | 2017-04-29 | | Release date: | 2018-04-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies
Oncotarget, 8, 2017
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5ZTH
 | | Crystal structure of spRlmCD with U1939loop RNA at 3.24 angstrom | | Descriptor: | RNA (5'-R(P*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | | Authors: | Jiang, Y.Y, Yu, H.L. | | Deposit date: | 2018-05-03 | | Release date: | 2018-10-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.24 Å) | | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
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1MKW
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2RSD
 | | Solution structure of the plant homeodomain (PHD) of the E3 SUMO ligase Siz1 from rice | | Descriptor: | E3 SUMO-protein ligase SIZ1, ZINC ION | | Authors: | Shindo, H, Tsuchiya, W, Suzuki, R, Yamazaki, T. | | Deposit date: | 2012-01-12 | | Release date: | 2012-08-15 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2
Febs Lett., 586, 2012
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6UIN
 | | Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex | | Descriptor: | DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*NP*NP*NP*NP*GP*GP*AP*TP*GP*TP*CP*GP*AP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*CP*CP*CP*CP*CP*TP*AP*CP*AP*A)-3'), DNA repair protein RAD4, ... | | Authors: | Paul, D, Min, J.-H. | | Deposit date: | 2019-10-01 | | Release date: | 2020-10-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.348 Å) | | Cite: | Tethering-facilitated DNA 'opening' and complementary roles of beta-hairpin motifs in the Rad4/XPC DNA damage sensor protein
Nucleic Acids Res., 48, 2021
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4FJZ
 | | Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63 | | Descriptor: | 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine], Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Whittington, D.A, Tang, J, Yakowec, P. | | Deposit date: | 2012-06-12 | | Release date: | 2012-10-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
J.Med.Chem., 55, 2012
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4FJY
 | | Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f | | Descriptor: | 4-[3,3-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1H-indol-1-yl]-7-fluoro-3-methyl-2-(pyridin-3-yl)quinoline, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Whittington, D.A, Tang, J, Yakowec, P. | | Deposit date: | 2012-06-12 | | Release date: | 2012-10-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
J.Med.Chem., 55, 2012
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5B6F
 | | Crystal structure of the Fab fragment of an anti-Leukotriene C4 monoclonal antibody complexed with LTC4 | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... | | Authors: | Sugahara, M, Ago, H, Saino, H, Miyano, M. | | Deposit date: | 2016-05-27 | | Release date: | 2017-05-31 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the Fab fragment of an anti-Leukotriene C4 monoclonal antibody complexed with LTC4
To Be Published
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5B86
 | | Crystal structure of M-Sec | | Descriptor: | Tumor necrosis factor alpha-induced protein 2 | | Authors: | Yamashita, M, Sato, Y, Yamagata, A, Fukai, S. | | Deposit date: | 2016-06-12 | | Release date: | 2016-10-12 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (3.017 Å) | | Cite: | Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation.
Sci Rep, 6, 2016
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