6BS1
Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
Summary for 6BS1
Entry DOI | 10.2210/pdb6bs1/pdb |
Related | 6BRX |
Descriptor | DNA polymerase kappa, DNA (5'-D(P*AP*TP*AP*CP*AP*TP*AP*CP*C)-3'), DNA (5'-D(*TP*AP*CP*TP*GP*GP*TP*AP*TP*GP*TP*AP*T)-3'), ... (8 entities in total) |
Functional Keywords | cisplatin, dna adduct, translesion dna synthesis, polymerase kappa, chemoresistance, replication |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 142803.44 |
Authors | |
Primary citation | Jha, V.,Ling, H. Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender. J. Mol. Biol., 430:1577-1589, 2018 Cited by PubMed: 29715472DOI: 10.1016/j.jmb.2018.04.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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