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6BS1

Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion

Summary for 6BS1
Entry DOI10.2210/pdb6bs1/pdb
Related6BRX
DescriptorDNA polymerase kappa, DNA (5'-D(P*AP*TP*AP*CP*AP*TP*AP*CP*C)-3'), DNA (5'-D(*TP*AP*CP*TP*GP*GP*TP*AP*TP*GP*TP*AP*T)-3'), ... (8 entities in total)
Functional Keywordscisplatin, dna adduct, translesion dna synthesis, polymerase kappa, chemoresistance, replication
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight142803.44
Authors
Jha, V.K.,Ling, H. (deposition date: 2017-12-01, release date: 2018-08-22, Last modification date: 2022-04-27)
Primary citationJha, V.,Ling, H.
Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
J. Mol. Biol., 430:1577-1589, 2018
Cited by
PubMed: 29715472
DOI: 10.1016/j.jmb.2018.04.023
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.15 Å)
Structure validation

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