5DOU
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form
Summary for 5DOU
| Entry DOI | 10.2210/pdb5dou/pdb |
| Related | 5DOT |
| Descriptor | Carbamoyl-phosphate synthase [ammonia], mitochondrial, 1,2-ETHANEDIOL, NICKEL (II) ION, ... (11 entities in total) |
| Functional Keywords | ligase, carbamoyl phosphate synthase (ammonia utilizing), carbamoyl phosphate, ammonia, n-acetyl-l-glutamate, adenosine triphosphate, ligand-bound, urea cycle, multi-domain, allosteric site, rare disease, cps1 deficiency, hyperammonemia |
| Biological source | Homo sapiens (Human) |
| Cellular location | Mitochondrion : P31327 |
| Total number of polymer chains | 4 |
| Total formula weight | 662384.15 |
| Authors | de Cima, S.,Polo, L.M.,Fita, I.,Rubio, V. (deposition date: 2015-09-11, release date: 2015-12-09, Last modification date: 2024-01-10) |
| Primary citation | de Cima, S.,Polo, L.M.,Diez-Fernandez, C.,Martinez, A.I.,Cervera, J.,Fita, I.,Rubio, V. Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5:16950-16950, 2015 Cited by PubMed: 26592762DOI: 10.1038/srep16950 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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