5DOU
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Carbamoyl-phosphate synthase [ammonia], mitochondrial | polymer | 1489 | 164061.8 | 4 | UniProt (P31327) Pfam (PF00988) Pfam (PF00117) Pfam (PF02786) Pfam (PF02787) Pfam (PF02142) In PDB | Homo sapiens (Human) | Carbamoyl-phosphate synthetase I,CPSase I |
| 2 | A, C, D, B | NICKEL (II) ION | non-polymer | 58.7 | 4 | Chemie (NI) | |||
| 3 | D, B, A, C | MAGNESIUM ION | non-polymer | 24.3 | 12 | Chemie (MG) | |||
| 4 | D, B, A, C | POTASSIUM ION | non-polymer | 39.1 | 18 | Chemie (K) | |||
| 5 | B, A, C, D | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 6 | D, B, A, C | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 8 | Chemie (ADP) | |||
| 7 | D, B, A, C | N-ACETYL-L-GLUTAMATE | non-polymer | 189.2 | 4 | Chemie (NLG) | |||
| 8 | D, B, A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 9 | D, A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 10 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 11 | water | water | 18.0 | 640 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 40 - 1500 (UniProt: P31327)
| PDB | External Database | Details |
|---|---|---|
| Met 12 | - | initiating methionine |
| Ser 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Tyr 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| Asp 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Ile 25 | - | expression tag |
| Pro 26 | - | expression tag |
| Thr 27 | - | expression tag |
| Thr 28 | - | expression tag |
| Glu 29 | - | expression tag |
| Asn 30 | - | expression tag |
| Leu 31 | - | expression tag |
| Tyr 32 | - | expression tag |
| Phe 33 | - | expression tag |
| Gln 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Ala 36 | - | expression tag |
| Met 37 | - | expression tag |
| Asp 38 | - | expression tag |
| Pro 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 656247.2 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 6137.0 | |
| All* | Total formula weight | 662384.2 |
