5DOU
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000050 | biological_process | urea cycle |
| A | 0001889 | biological_process | liver development |
| A | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0007494 | biological_process | midgut development |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0010043 | biological_process | response to zinc ion |
| A | 0014075 | biological_process | response to amine |
| A | 0016595 | molecular_function | glutamate binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0019433 | biological_process | triglyceride catabolic process |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0032094 | biological_process | response to food |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033762 | biological_process | response to glucagon |
| A | 0034201 | biological_process | response to oleic acid |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0042311 | biological_process | vasodilation |
| A | 0042594 | biological_process | response to starvation |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0043200 | biological_process | response to amino acid |
| A | 0044344 | biological_process | cellular response to fibroblast growth factor stimulus |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0046209 | biological_process | nitric oxide metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048545 | biological_process | response to steroid hormone |
| A | 0050667 | biological_process | homocysteine metabolic process |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0051591 | biological_process | response to cAMP |
| A | 0055081 | biological_process | monoatomic anion homeostasis |
| A | 0060416 | biological_process | response to growth hormone |
| A | 0070365 | biological_process | hepatocyte differentiation |
| A | 0070409 | biological_process | carbamoyl phosphate biosynthetic process |
| A | 0071242 | biological_process | cellular response to ammonium ion |
| A | 0071320 | biological_process | cellular response to cAMP |
| A | 0071377 | biological_process | cellular response to glucagon stimulus |
| A | 0071400 | biological_process | cellular response to oleic acid |
| A | 0071548 | biological_process | response to dexamethasone |
| A | 0072341 | molecular_function | modified amino acid binding |
| B | 0000050 | biological_process | urea cycle |
| B | 0001889 | biological_process | liver development |
| B | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| B | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| B | 0004175 | molecular_function | endopeptidase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006541 | biological_process | glutamine metabolic process |
| B | 0007494 | biological_process | midgut development |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0010043 | biological_process | response to zinc ion |
| B | 0014075 | biological_process | response to amine |
| B | 0016595 | molecular_function | glutamate binding |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0019433 | biological_process | triglyceride catabolic process |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0032094 | biological_process | response to food |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033762 | biological_process | response to glucagon |
| B | 0034201 | biological_process | response to oleic acid |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0042311 | biological_process | vasodilation |
| B | 0042594 | biological_process | response to starvation |
| B | 0042645 | cellular_component | mitochondrial nucleoid |
| B | 0043200 | biological_process | response to amino acid |
| B | 0044344 | biological_process | cellular response to fibroblast growth factor stimulus |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0046209 | biological_process | nitric oxide metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048545 | biological_process | response to steroid hormone |
| B | 0050667 | biological_process | homocysteine metabolic process |
| B | 0051384 | biological_process | response to glucocorticoid |
| B | 0051591 | biological_process | response to cAMP |
| B | 0055081 | biological_process | monoatomic anion homeostasis |
| B | 0060416 | biological_process | response to growth hormone |
| B | 0070365 | biological_process | hepatocyte differentiation |
| B | 0070409 | biological_process | carbamoyl phosphate biosynthetic process |
| B | 0071242 | biological_process | cellular response to ammonium ion |
| B | 0071320 | biological_process | cellular response to cAMP |
| B | 0071377 | biological_process | cellular response to glucagon stimulus |
| B | 0071400 | biological_process | cellular response to oleic acid |
| B | 0071548 | biological_process | response to dexamethasone |
| B | 0072341 | molecular_function | modified amino acid binding |
| C | 0000050 | biological_process | urea cycle |
| C | 0001889 | biological_process | liver development |
| C | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| C | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| C | 0004175 | molecular_function | endopeptidase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006541 | biological_process | glutamine metabolic process |
| C | 0007494 | biological_process | midgut development |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0010043 | biological_process | response to zinc ion |
| C | 0014075 | biological_process | response to amine |
| C | 0016595 | molecular_function | glutamate binding |
| C | 0016874 | molecular_function | ligase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0019433 | biological_process | triglyceride catabolic process |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0032094 | biological_process | response to food |
| C | 0032496 | biological_process | response to lipopolysaccharide |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0033762 | biological_process | response to glucagon |
| C | 0034201 | biological_process | response to oleic acid |
| C | 0036094 | molecular_function | small molecule binding |
| C | 0042311 | biological_process | vasodilation |
| C | 0042594 | biological_process | response to starvation |
| C | 0042645 | cellular_component | mitochondrial nucleoid |
| C | 0043200 | biological_process | response to amino acid |
| C | 0044344 | biological_process | cellular response to fibroblast growth factor stimulus |
| C | 0044877 | molecular_function | protein-containing complex binding |
| C | 0046209 | biological_process | nitric oxide metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048545 | biological_process | response to steroid hormone |
| C | 0050667 | biological_process | homocysteine metabolic process |
| C | 0051384 | biological_process | response to glucocorticoid |
| C | 0051591 | biological_process | response to cAMP |
| C | 0055081 | biological_process | monoatomic anion homeostasis |
| C | 0060416 | biological_process | response to growth hormone |
| C | 0070365 | biological_process | hepatocyte differentiation |
| C | 0070409 | biological_process | carbamoyl phosphate biosynthetic process |
| C | 0071242 | biological_process | cellular response to ammonium ion |
| C | 0071320 | biological_process | cellular response to cAMP |
| C | 0071377 | biological_process | cellular response to glucagon stimulus |
| C | 0071400 | biological_process | cellular response to oleic acid |
| C | 0071548 | biological_process | response to dexamethasone |
| C | 0072341 | molecular_function | modified amino acid binding |
| D | 0000050 | biological_process | urea cycle |
| D | 0001889 | biological_process | liver development |
| D | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
| D | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
| D | 0004175 | molecular_function | endopeptidase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005543 | molecular_function | phospholipid binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005730 | cellular_component | nucleolus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006541 | biological_process | glutamine metabolic process |
| D | 0007494 | biological_process | midgut development |
| D | 0009410 | biological_process | response to xenobiotic stimulus |
| D | 0009636 | biological_process | response to toxic substance |
| D | 0010043 | biological_process | response to zinc ion |
| D | 0014075 | biological_process | response to amine |
| D | 0016595 | molecular_function | glutamate binding |
| D | 0016874 | molecular_function | ligase activity |
| D | 0019240 | biological_process | citrulline biosynthetic process |
| D | 0019433 | biological_process | triglyceride catabolic process |
| D | 0030955 | molecular_function | potassium ion binding |
| D | 0032094 | biological_process | response to food |
| D | 0032496 | biological_process | response to lipopolysaccharide |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0033762 | biological_process | response to glucagon |
| D | 0034201 | biological_process | response to oleic acid |
| D | 0036094 | molecular_function | small molecule binding |
| D | 0042311 | biological_process | vasodilation |
| D | 0042594 | biological_process | response to starvation |
| D | 0042645 | cellular_component | mitochondrial nucleoid |
| D | 0043200 | biological_process | response to amino acid |
| D | 0044344 | biological_process | cellular response to fibroblast growth factor stimulus |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0046209 | biological_process | nitric oxide metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048545 | biological_process | response to steroid hormone |
| D | 0050667 | biological_process | homocysteine metabolic process |
| D | 0051384 | biological_process | response to glucocorticoid |
| D | 0051591 | biological_process | response to cAMP |
| D | 0055081 | biological_process | monoatomic anion homeostasis |
| D | 0060416 | biological_process | response to growth hormone |
| D | 0070365 | biological_process | hepatocyte differentiation |
| D | 0070409 | biological_process | carbamoyl phosphate biosynthetic process |
| D | 0071242 | biological_process | cellular response to ammonium ion |
| D | 0071320 | biological_process | cellular response to cAMP |
| D | 0071377 | biological_process | cellular response to glucagon stimulus |
| D | 0071400 | biological_process | cellular response to oleic acid |
| D | 0071548 | biological_process | response to dexamethasone |
| D | 0072341 | molecular_function | modified amino acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NI A 2001 |
| Chain | Residue |
| A | ASN315 |
| A | GLN335 |
| A | HIS337 |
| A | GLU362 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 2002 |
| Chain | Residue |
| A | HOH2114 |
| A | GLU714 |
| A | ASN716 |
| A | MG2003 |
| A | PO42007 |
| A | ADP2008 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 2003 |
| Chain | Residue |
| A | GLN700 |
| A | GLU714 |
| A | MG2002 |
| A | PO42007 |
| A | ADP2008 |
| A | HOH2206 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue K A 2004 |
| Chain | Residue |
| A | GLU631 |
| A | ASN652 |
| A | ASP654 |
| A | ALA655 |
| A | VAL658 |
| A | SER663 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue K A 2005 |
| Chain | Residue |
| A | THR544 |
| A | GLU545 |
| A | GLU714 |
| A | VAL715 |
| A | ASN716 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue K A 2006 |
| Chain | Residue |
| A | GLU633 |
| A | THR660 |
| A | ASN698 |
| A | GLN700 |
| A | SER722 |
| A | PO42007 |
| A | HOH2314 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue PO4 A 2007 |
| Chain | Residue |
| A | LEU592 |
| A | GLY593 |
| A | HIS659 |
| A | GLN700 |
| A | GLU714 |
| A | ASN716 |
| A | ARG718 |
| A | ARG721 |
| A | MG2002 |
| A | MG2003 |
| A | K2006 |
| A | ADP2008 |
| A | HOH2114 |
| A | HOH2206 |
| A | HOH2278 |
| A | HOH2314 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | binding site for residue ADP A 2008 |
| Chain | Residue |
| A | ARG547 |
| A | MET585 |
| A | ARG587 |
| A | ALA591 |
| A | LEU592 |
| A | GLY593 |
| A | GLY594 |
| A | GLU623 |
| A | LYS624 |
| A | SER625 |
| A | VAL626 |
| A | THR627 |
| A | GLU631 |
| A | MET656 |
| A | GLY657 |
| A | VAL658 |
| A | HIS659 |
| A | THR660 |
| A | GLN700 |
| A | ILE713 |
| A | GLU714 |
| A | SER790 |
| A | MG2002 |
| A | MG2003 |
| A | PO42007 |
| A | HOH2114 |
| A | HOH2206 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue ADP A 2009 |
| Chain | Residue |
| A | LEU1127 |
| A | ARG1129 |
| A | MET1139 |
| A | LYS1168 |
| A | PHE1169 |
| A | VAL1170 |
| A | GLU1175 |
| A | ALA1199 |
| A | GLY1200 |
| A | VAL1201 |
| A | HIS1202 |
| A | SER1203 |
| A | GLN1243 |
| A | LEU1245 |
| A | ILE1254 |
| A | GLU1255 |
| A | MG2011 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for residue NLG A 2010 |
| Chain | Residue |
| A | TRP1410 |
| A | LEU1438 |
| A | THR1443 |
| A | LYS1444 |
| A | PHE1445 |
| A | ASN1449 |
| A | HOH2131 |
| A | HOH2158 |
| A | HOH2220 |
| A | ILE1366 |
| A | GLN1367 |
| A | THR1391 |
| A | ALA1393 |
| A | THR1394 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 2011 |
| Chain | Residue |
| A | GLN1243 |
| A | GLU1255 |
| A | ADP2009 |
| A | HOH2320 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 2012 |
| Chain | Residue |
| A | ARG1259 |
| A | SER1261 |
| A | ARG1262 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue K A 2013 |
| Chain | Residue |
| A | LEU778 |
| A | PHE781 |
| A | THR784 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue K A 2014 |
| Chain | Residue |
| A | LYS892 |
| A | LEU894 |
| A | CYS920 |
| A | HOH2263 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 2015 |
| Chain | Residue |
| A | ALA330 |
| A | PHE331 |
| A | ILE332 |
| A | ASP386 |
| A | CYS644 |
| A | ARG682 |
| A | ARG689 |
| A | HOH2101 |
| A | HOH2165 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 2016 |
| Chain | Residue |
| A | GLU473 |
| A | SER1268 |
| A | GLY1272 |
| A | VAL1273 |
| A | ASP1274 |
| A | HOH2312 |
| A | HOH2324 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue NI B 2001 |
| Chain | Residue |
| B | ASN315 |
| B | GLN335 |
| B | HIS337 |
| B | THR360 |
| B | GLU362 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 2002 |
| Chain | Residue |
| B | ALA591 |
| B | GLU714 |
| B | ASN716 |
| B | K2005 |
| B | PO42007 |
| B | ADP2008 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 2003 |
| Chain | Residue |
| B | HIS659 |
| B | GLN700 |
| B | GLU714 |
| B | K2006 |
| B | PO42007 |
| B | ADP2008 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue K B 2004 |
| Chain | Residue |
| B | GLU631 |
| B | ASN652 |
| B | ASP654 |
| B | ALA655 |
| B | VAL658 |
| B | SER663 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue K B 2005 |
| Chain | Residue |
| B | THR544 |
| B | GLU545 |
| B | GLU714 |
| B | VAL715 |
| B | ASN716 |
| B | MG2002 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue K B 2006 |
| Chain | Residue |
| B | GLU633 |
| B | THR660 |
| B | ASN698 |
| B | GLN700 |
| B | SER722 |
| B | MG2003 |
| B | PO42007 |
| B | HOH2135 |
| site_id | AE5 |
| Number of Residues | 13 |
| Details | binding site for residue PO4 B 2007 |
| Chain | Residue |
| B | LEU592 |
| B | GLY593 |
| B | HIS659 |
| B | GLN700 |
| B | GLU714 |
| B | ASN716 |
| B | ARG718 |
| B | ARG721 |
| B | MG2002 |
| B | MG2003 |
| B | K2006 |
| B | ADP2008 |
| B | HOH2135 |
| site_id | AE6 |
| Number of Residues | 24 |
| Details | binding site for residue ADP B 2008 |
| Chain | Residue |
| B | ARG547 |
| B | MET585 |
| B | ARG587 |
| B | ALA591 |
| B | LEU592 |
| B | GLY593 |
| B | GLY594 |
| B | GLU623 |
| B | LYS624 |
| B | VAL626 |
| B | THR627 |
| B | GLU631 |
| B | MET656 |
| B | GLY657 |
| B | VAL658 |
| B | HIS659 |
| B | THR660 |
| B | GLN700 |
| B | ILE713 |
| B | GLU714 |
| B | SER790 |
| B | MG2002 |
| B | MG2003 |
| B | PO42007 |
| site_id | AE7 |
| Number of Residues | 17 |
| Details | binding site for residue ADP B 2009 |
| Chain | Residue |
| B | ALA1104 |
| B | LEU1127 |
| B | MET1139 |
| B | LYS1168 |
| B | PHE1169 |
| B | VAL1170 |
| B | GLU1175 |
| B | ALA1199 |
| B | GLY1200 |
| B | VAL1201 |
| B | HIS1202 |
| B | SER1203 |
| B | GLN1243 |
| B | LEU1245 |
| B | ILE1254 |
| B | GLU1255 |
| B | MG2011 |
| site_id | AE8 |
| Number of Residues | 14 |
| Details | binding site for residue NLG B 2010 |
| Chain | Residue |
| B | ILE1366 |
| B | GLN1367 |
| B | THR1391 |
| B | GLU1392 |
| B | ALA1393 |
| B | THR1394 |
| B | TRP1410 |
| B | LEU1438 |
| B | THR1443 |
| B | LYS1444 |
| B | PHE1445 |
| B | ASN1449 |
| B | HOH2130 |
| B | HOH2139 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 2011 |
| Chain | Residue |
| B | GLN1243 |
| B | GLU1255 |
| B | ADP2009 |
| B | HOH2178 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 2012 |
| Chain | Residue |
| B | ARG1259 |
| B | ARG1262 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue K B 2013 |
| Chain | Residue |
| B | GLU1175 |
| B | HIS1195 |
| B | GLU1197 |
| B | ASP1198 |
| B | VAL1201 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue NI C 2001 |
| Chain | Residue |
| C | ASN315 |
| C | GLN335 |
| C | HIS337 |
| C | THR360 |
| C | ASN361 |
| C | GLU362 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 2002 |
| Chain | Residue |
| C | ALA591 |
| C | GLU714 |
| C | ASN716 |
| C | ARG718 |
| C | K2005 |
| C | PO42007 |
| C | ADP2008 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 2003 |
| Chain | Residue |
| C | HIS659 |
| C | GLN700 |
| C | GLU714 |
| C | K2006 |
| C | PO42007 |
| C | ADP2008 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue K C 2004 |
| Chain | Residue |
| C | GLU631 |
| C | ASN652 |
| C | ASP654 |
| C | ALA655 |
| C | VAL658 |
| C | SER663 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue K C 2005 |
| Chain | Residue |
| C | THR544 |
| C | GLU545 |
| C | GLU714 |
| C | VAL715 |
| C | ASN716 |
| C | MG2002 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue K C 2006 |
| Chain | Residue |
| C | THR660 |
| C | ASN698 |
| C | GLN700 |
| C | ASN716 |
| C | MG2003 |
| C | PO42007 |
| C | HOH2128 |
| site_id | AF9 |
| Number of Residues | 13 |
| Details | binding site for residue PO4 C 2007 |
| Chain | Residue |
| C | LEU592 |
| C | GLY593 |
| C | HIS659 |
| C | GLN700 |
| C | GLU714 |
| C | ASN716 |
| C | ARG718 |
| C | ARG721 |
| C | MG2002 |
| C | MG2003 |
| C | K2006 |
| C | ADP2008 |
| C | HOH2128 |
| site_id | AG1 |
| Number of Residues | 25 |
| Details | binding site for residue ADP C 2008 |
| Chain | Residue |
| C | ARG547 |
| C | MET585 |
| C | ARG587 |
| C | ALA591 |
| C | LEU592 |
| C | GLY593 |
| C | GLY594 |
| C | GLU623 |
| C | LYS624 |
| C | SER625 |
| C | VAL626 |
| C | THR627 |
| C | GLU631 |
| C | MET656 |
| C | GLY657 |
| C | VAL658 |
| C | HIS659 |
| C | THR660 |
| C | GLN700 |
| C | GLU714 |
| C | SER790 |
| C | MG2002 |
| C | MG2003 |
| C | PO42007 |
| C | HOH2129 |
| site_id | AG2 |
| Number of Residues | 15 |
| Details | binding site for residue ADP C 2009 |
| Chain | Residue |
| C | LEU1127 |
| C | ARG1129 |
| C | LYS1168 |
| C | PHE1169 |
| C | VAL1170 |
| C | GLU1175 |
| C | ALA1199 |
| C | GLY1200 |
| C | VAL1201 |
| C | HIS1202 |
| C | SER1203 |
| C | GLN1243 |
| C | LEU1245 |
| C | GLU1255 |
| C | MG2011 |
| site_id | AG3 |
| Number of Residues | 13 |
| Details | binding site for residue NLG C 2010 |
| Chain | Residue |
| C | ILE1366 |
| C | GLN1367 |
| C | THR1391 |
| C | ALA1393 |
| C | THR1394 |
| C | TRP1410 |
| C | LEU1438 |
| C | THR1443 |
| C | LYS1444 |
| C | PHE1445 |
| C | ASN1449 |
| C | HOH2133 |
| C | HOH2137 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 2011 |
| Chain | Residue |
| C | GLN1243 |
| C | GLU1255 |
| C | ADP2009 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue K C 2012 |
| Chain | Residue |
| C | GLU1175 |
| C | HIS1195 |
| C | GLU1197 |
| C | ASP1198 |
| C | VAL1201 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue NI D 2001 |
| Chain | Residue |
| D | ASN315 |
| D | GLN335 |
| D | HIS337 |
| D | GLU362 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 2002 |
| Chain | Residue |
| D | GLU714 |
| D | ASN716 |
| D | K2005 |
| D | PO42007 |
| D | ADP2008 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 2003 |
| Chain | Residue |
| D | GLN700 |
| D | GLU714 |
| D | PO42007 |
| D | ADP2008 |
| site_id | AG9 |
| Number of Residues | 6 |
| Details | binding site for residue K D 2004 |
| Chain | Residue |
| D | GLU631 |
| D | ASN652 |
| D | ASP654 |
| D | ALA655 |
| D | VAL658 |
| D | SER663 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue K D 2005 |
| Chain | Residue |
| D | THR544 |
| D | GLU545 |
| D | GLU714 |
| D | VAL715 |
| D | ASN716 |
| D | MG2002 |
| site_id | AH2 |
| Number of Residues | 7 |
| Details | binding site for residue K D 2006 |
| Chain | Residue |
| D | GLU633 |
| D | THR660 |
| D | ASN698 |
| D | GLN700 |
| D | SER722 |
| D | PO42007 |
| D | HOH2252 |
| site_id | AH3 |
| Number of Residues | 13 |
| Details | binding site for residue PO4 D 2007 |
| Chain | Residue |
| D | LEU592 |
| D | GLY593 |
| D | HIS659 |
| D | GLN700 |
| D | GLU714 |
| D | ASN716 |
| D | ARG718 |
| D | ARG721 |
| D | MG2002 |
| D | MG2003 |
| D | K2006 |
| D | ADP2008 |
| D | HOH2252 |
| site_id | AH4 |
| Number of Residues | 25 |
| Details | binding site for residue ADP D 2008 |
| Chain | Residue |
| D | ARG547 |
| D | MET585 |
| D | ARG587 |
| D | ALA591 |
| D | LEU592 |
| D | GLY593 |
| D | GLY594 |
| D | GLU623 |
| D | LYS624 |
| D | SER625 |
| D | VAL626 |
| D | THR627 |
| D | GLU631 |
| D | MET656 |
| D | GLY657 |
| D | VAL658 |
| D | HIS659 |
| D | THR660 |
| D | GLN700 |
| D | ILE713 |
| D | GLU714 |
| D | SER790 |
| D | MG2002 |
| D | MG2003 |
| D | PO42007 |
| site_id | AH5 |
| Number of Residues | 16 |
| Details | binding site for residue ADP D 2009 |
| Chain | Residue |
| D | LEU1127 |
| D | ARG1129 |
| D | LYS1168 |
| D | PHE1169 |
| D | VAL1170 |
| D | GLU1175 |
| D | ALA1199 |
| D | GLY1200 |
| D | VAL1201 |
| D | HIS1202 |
| D | SER1203 |
| D | GLN1243 |
| D | LEU1245 |
| D | GLU1255 |
| D | MG2011 |
| D | HOH2102 |
| site_id | AH6 |
| Number of Residues | 13 |
| Details | binding site for residue NLG D 2010 |
| Chain | Residue |
| D | ILE1366 |
| D | GLN1367 |
| D | THR1391 |
| D | GLU1392 |
| D | ALA1393 |
| D | THR1394 |
| D | TRP1410 |
| D | LEU1438 |
| D | THR1443 |
| D | LYS1444 |
| D | PHE1445 |
| D | ASN1449 |
| D | HOH2107 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 2011 |
| Chain | Residue |
| D | GLN1243 |
| D | GLU1255 |
| D | ADP2009 |
| D | HOH2102 |
| D | HOH2308 |
| site_id | AH8 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 2012 |
| Chain | Residue |
| D | ARG1259 |
| D | SER1261 |
| D | ARG1262 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue K D 2013 |
| Chain | Residue |
| D | LYS892 |
| D | LEU894 |
| D | CYS920 |
| D | HOH2267 |
| site_id | AI1 |
| Number of Residues | 3 |
| Details | binding site for residue K D 2014 |
| Chain | Residue |
| D | LEU778 |
| D | PHE781 |
| D | THR784 |
| site_id | AI2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 2015 |
| Chain | Residue |
| D | ALA330 |
| D | PHE331 |
| D | ILE332 |
| D | ASP386 |
| D | CYS644 |
| D | ARG682 |
| D | ARG689 |
| D | HOH2137 |
| D | HOH2152 |
Functional Information from PROSITE/UniProt
| site_id | PS00866 |
| Number of Residues | 15 |
| Details | CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIRSAyalGGlG |
| Chain | Residue | Details |
| A | TYR582-GLY596 | |
| A | TYR1124-ALA1138 |
| site_id | PS00867 |
| Number of Residues | 8 |
| Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. IIEVNARL |
| Chain | Residue | Details |
| A | ILE712-LEU719 | |
| A | VAL1253-ALA1260 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | THR1391 | |
| B | ASN1437 | |
| B | ASN1440 | |
| B | ASN1449 | |
| C | THR1391 | |
| C | THR1394 | |
| C | TRP1410 | |
| C | ASN1437 | |
| C | ASN1440 | |
| C | ASN1449 | |
| D | THR1391 | |
| A | THR1394 | |
| D | THR1394 | |
| D | TRP1410 | |
| D | ASN1437 | |
| D | ASN1440 | |
| D | ASN1449 | |
| A | TRP1410 | |
| A | ASN1437 | |
| A | ASN1440 | |
| A | ASN1449 | |
| B | THR1391 | |
| B | THR1394 | |
| B | TRP1410 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 156 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8C196 |
| Chain | Residue | Details |
| A | LYS55 | |
| A | LYS412 | |
| C | LYS875 | |
| C | LYS889 | |
| C | LYS892 | |
| C | LYS915 | |
| C | LYS919 | |
| C | LYS1074 | |
| C | LYS1100 | |
| C | LYS1168 | |
| C | LYS1183 | |
| C | LYS1232 | |
| A | LYS458 | |
| C | LYS1269 | |
| C | LYS1291 | |
| C | LYS1356 | |
| C | LYS1360 | |
| C | LYS1444 | |
| C | LYS1471 | |
| C | LYS1479 | |
| C | LYS1486 | |
| D | LYS55 | |
| D | LYS57 | |
| A | LYS522 | |
| D | LYS119 | |
| D | LYS157 | |
| D | LYS207 | |
| D | LYS214 | |
| D | LYS287 | |
| D | LYS307 | |
| D | LYS402 | |
| D | LYS412 | |
| D | LYS458 | |
| D | LYS522 | |
| A | LYS527 | |
| D | LYS527 | |
| D | LYS553 | |
| D | LYS560 | |
| D | LYS575 | |
| D | LYS612 | |
| D | LYS751 | |
| D | LYS757 | |
| D | LYS793 | |
| D | LYS831 | |
| D | LYS875 | |
| A | LYS553 | |
| D | LYS889 | |
| D | LYS892 | |
| D | LYS915 | |
| D | LYS919 | |
| D | LYS1074 | |
| D | LYS1100 | |
| D | LYS1168 | |
| D | LYS1183 | |
| D | LYS1232 | |
| D | LYS1269 | |
| A | LYS560 | |
| D | LYS1291 | |
| D | LYS1356 | |
| D | LYS1360 | |
| D | LYS1444 | |
| D | LYS1471 | |
| D | LYS1479 | |
| D | LYS1486 | |
| A | LYS575 | |
| A | LYS612 | |
| A | LYS751 | |
| A | LYS757 | |
| A | LYS57 | |
| A | LYS793 | |
| A | LYS831 | |
| A | LYS875 | |
| A | LYS889 | |
| A | LYS892 | |
| A | LYS915 | |
| A | LYS919 | |
| A | LYS1074 | |
| A | LYS1100 | |
| A | LYS1168 | |
| A | LYS119 | |
| A | LYS1183 | |
| A | LYS1232 | |
| A | LYS1269 | |
| A | LYS1291 | |
| A | LYS1356 | |
| A | LYS1360 | |
| A | LYS1444 | |
| A | LYS1471 | |
| A | LYS1479 | |
| A | LYS1486 | |
| A | LYS157 | |
| B | LYS55 | |
| B | LYS57 | |
| B | LYS119 | |
| B | LYS157 | |
| B | LYS207 | |
| B | LYS214 | |
| B | LYS287 | |
| B | LYS307 | |
| B | LYS402 | |
| B | LYS412 | |
| A | LYS207 | |
| B | LYS458 | |
| B | LYS522 | |
| B | LYS527 | |
| B | LYS553 | |
| B | LYS560 | |
| B | LYS575 | |
| B | LYS612 | |
| B | LYS751 | |
| B | LYS757 | |
| B | LYS793 | |
| A | LYS214 | |
| B | LYS831 | |
| B | LYS875 | |
| B | LYS889 | |
| B | LYS892 | |
| B | LYS915 | |
| B | LYS919 | |
| B | LYS1074 | |
| B | LYS1100 | |
| B | LYS1168 | |
| B | LYS1183 | |
| A | LYS287 | |
| B | LYS1232 | |
| B | LYS1269 | |
| B | LYS1291 | |
| B | LYS1356 | |
| B | LYS1360 | |
| B | LYS1444 | |
| B | LYS1471 | |
| B | LYS1479 | |
| B | LYS1486 | |
| C | LYS55 | |
| A | LYS307 | |
| C | LYS57 | |
| C | LYS119 | |
| C | LYS157 | |
| C | LYS207 | |
| C | LYS214 | |
| C | LYS287 | |
| C | LYS307 | |
| C | LYS402 | |
| C | LYS412 | |
| C | LYS458 | |
| A | LYS402 | |
| C | LYS522 | |
| C | LYS527 | |
| C | LYS553 | |
| C | LYS560 | |
| C | LYS575 | |
| C | LYS612 | |
| C | LYS751 | |
| C | LYS757 | |
| C | LYS793 | |
| C | LYS831 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER148 | |
| B | SER1203 | |
| B | SER1419 | |
| B | SER1431 | |
| C | SER148 | |
| C | SER569 | |
| C | SER835 | |
| C | SER1203 | |
| C | SER1419 | |
| C | SER1431 | |
| D | SER148 | |
| A | SER569 | |
| D | SER569 | |
| D | SER835 | |
| D | SER1203 | |
| D | SER1419 | |
| D | SER1431 | |
| A | SER835 | |
| A | SER1203 | |
| A | SER1419 | |
| A | SER1431 | |
| B | SER148 | |
| B | SER569 | |
| B | SER835 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:24703693 |
| Chain | Residue | Details |
| A | LYS171 | |
| A | LYS811 | |
| A | LYS841 | |
| A | LYS856 | |
| A | LYS908 | |
| B | LYS171 | |
| B | LYS210 | |
| B | LYS219 | |
| B | LYS228 | |
| B | LYS280 | |
| B | LYS310 | |
| A | LYS210 | |
| B | LYS453 | |
| B | LYS532 | |
| B | LYS772 | |
| B | LYS811 | |
| B | LYS841 | |
| B | LYS856 | |
| B | LYS908 | |
| C | LYS171 | |
| C | LYS210 | |
| C | LYS219 | |
| A | LYS219 | |
| C | LYS228 | |
| C | LYS280 | |
| C | LYS310 | |
| C | LYS453 | |
| C | LYS532 | |
| C | LYS772 | |
| C | LYS811 | |
| C | LYS841 | |
| C | LYS856 | |
| C | LYS908 | |
| A | LYS228 | |
| D | LYS171 | |
| D | LYS210 | |
| D | LYS219 | |
| D | LYS228 | |
| D | LYS280 | |
| D | LYS310 | |
| D | LYS453 | |
| D | LYS532 | |
| D | LYS772 | |
| D | LYS811 | |
| A | LYS280 | |
| D | LYS841 | |
| D | LYS856 | |
| D | LYS908 | |
| A | LYS310 | |
| A | LYS453 | |
| A | LYS532 | |
| A | LYS772 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 28 |
| Details | MOD_RES: N6-glutaryllysine => ECO:0000269|PubMed:24703693 |
| Chain | Residue | Details |
| A | LYS176 | |
| B | LYS728 | |
| B | LYS869 | |
| B | LYS905 | |
| B | LYS1150 | |
| B | LYS1224 | |
| C | LYS176 | |
| C | LYS237 | |
| C | LYS728 | |
| C | LYS869 | |
| C | LYS905 | |
| A | LYS237 | |
| C | LYS1150 | |
| C | LYS1224 | |
| D | LYS176 | |
| D | LYS237 | |
| D | LYS728 | |
| D | LYS869 | |
| D | LYS905 | |
| D | LYS1150 | |
| D | LYS1224 | |
| A | LYS728 | |
| A | LYS869 | |
| A | LYS905 | |
| A | LYS1150 | |
| A | LYS1224 | |
| B | LYS176 | |
| B | LYS237 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8C196 |
| Chain | Residue | Details |
| A | LYS182 | |
| B | LYS1222 | |
| C | LYS182 | |
| C | LYS197 | |
| C | LYS630 | |
| C | LYS935 | |
| C | LYS1222 | |
| D | LYS182 | |
| D | LYS197 | |
| D | LYS630 | |
| D | LYS935 | |
| A | LYS197 | |
| D | LYS1222 | |
| A | LYS630 | |
| A | LYS935 | |
| A | LYS1222 | |
| B | LYS182 | |
| B | LYS197 | |
| B | LYS630 | |
| B | LYS935 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8C196 |
| Chain | Residue | Details |
| A | LYS400 | |
| A | LYS1149 | |
| B | LYS400 | |
| B | LYS1149 | |
| C | LYS400 | |
| C | LYS1149 | |
| D | LYS400 | |
| D | LYS1149 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:Q8C196 |
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 | |
| C | SER537 | |
| D | SER537 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07756 |
| Chain | Residue | Details |
| A | SER540 | |
| B | SER1093 | |
| C | SER540 | |
| C | SER896 | |
| C | SER898 | |
| C | SER1090 | |
| C | SER1093 | |
| D | SER540 | |
| D | SER896 | |
| D | SER898 | |
| D | SER1090 | |
| A | SER896 | |
| D | SER1093 | |
| A | SER898 | |
| A | SER1090 | |
| A | SER1093 | |
| B | SER540 | |
| B | SER896 | |
| B | SER898 | |
| B | SER1090 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1036 | |
| B | SER1036 | |
| C | SER1036 | |
| D | SER1036 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER1079 | |
| B | SER1079 | |
| C | SER1079 | |
| D | SER1079 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250 |
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 | |
| C | SER537 | |
| D | SER537 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
| Chain | Residue | Details |
| A | SER1331 | |
| B | SER1331 | |
| C | SER1331 | |
| D | SER1331 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000250 |
| Chain | Residue | Details |
| A | THR1332 | |
| B | THR1332 | |
| C | THR1332 | |
| D | THR1332 |
