4EJJ
Human Cytochrome P450 2A6 in complex with nicotine
Summary for 4EJJ
| Entry DOI | 10.2210/pdb4ejj/pdb |
| Related | 1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 2PG5 2PG6 2PG7 3EBS 3T3R 4EJG 4EJH 4EJI |
| Descriptor | Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, ... (4 entities in total) |
| Functional Keywords | cytochrome p450 2a6, p450 2a6, heme protein, monoxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P11509 |
| Total number of polymer chains | 4 |
| Total formula weight | 221801.42 |
| Authors | DeVore, N.M.,Scott, E.E. (deposition date: 2012-04-06, release date: 2012-06-06, Last modification date: 2023-09-13) |
| Primary citation | DeVore, N.M.,Scott, E.E. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. J.Biol.Chem., 287:26576-26585, 2012 Cited by PubMed: 22700965DOI: 10.1074/jbc.M112.372813 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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