4EJJ
Human Cytochrome P450 2A6 in complex with nicotine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 2A6 | polymer | 476 | 54671.6 | 4 | UniProt (P11509) Pfam (PF00067) | Homo sapiens (human) | CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 IIA3, Cytochrome P450(I) |
| 2 | E, G, I, L (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, H, J, K (A, B, C, D) | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 4 | Chemie (NCT) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 29 - 494 (UniProt: P11509)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | initiating methionine |
| Ala 24 | - | expression tag |
| Lys 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Thr 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Tyr 392 | Phe 393 | SEE REMARK 999 |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 218686.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3114.9 | |
| All* | Total formula weight | 221801.4 |
