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5KQV

Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)

Replaces:  3W14
Summary for 5KQV
Entry DOI10.2210/pdb5kqv/pdb
Related4ZXB
DescriptorInsulin, MONOCLONAL ANTIBODY FAB 83-14 - HEAVY CHAIN, MONOCLONAL ANTIBODY FAB 83-14 - LIGHT CHAIN, ... (7 entities in total)
Functional Keywordscell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, hormone-hormone receptor-immune system complex, hormone/hormone receptor/immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains10
Total formula weight247027.06
Authors
Lawrence, M.C.,Smith, B.J.,Croll, T.I. (deposition date: 2016-07-06, release date: 2017-07-19, Last modification date: 2023-10-04)
Primary citationMenting, J.G.,Whittaker, J.,Margetts, M.B.,Whittaker, L.J.,Kong, G.K.,Smith, B.J.,Watson, C.J.,Zakova, L.,Kletvikova, E.,Jiracek, J.,Chan, S.J.,Steiner, D.F.,Dodson, G.G.,Brzozowski, A.M.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C.
How insulin engages its primary binding site on the insulin receptor.
Nature, 493:241-245, 2013
Cited by
PubMed: 23302862
DOI: 10.1038/nature11781
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4.4 Å)
Structure validation

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