5KQV
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
Replaces: 3W14Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G (A, I) | Insulin | polymer | 21 | 2339.6 | 2 | UniProt (P01317) | Bos taurus (Bovine) | |
| 2 | B, H (B, J) | Insulin | polymer | 30 | 3403.9 | 2 | UniProt (P01317) Pfam (PF00049) | Bos taurus (Bovine) | |
| 3 | C, I (C, P) | MONOCLONAL ANTIBODY FAB 83-14 - HEAVY CHAIN | polymer | 220 | 23622.7 | 2 | Mus musculus | ||
| 4 | D, J (D, Q) | MONOCLONAL ANTIBODY FAB 83-14 - LIGHT CHAIN | polymer | 214 | 23514.8 | 2 | Mus musculus | ||
| 5 | E, F (E, F) | Insulin receptor,Insulin receptor | polymer | 609 | 69979.9 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | IR,IR |
| 6 | K, L (G, H) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 7 | M (K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) |
Sequence modifications
E, F: 1 - 593 (UniProt: P06213)
E, F: 594 - 609 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 245721.8 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1305.2 | |
| All* | Total formula weight | 247027.1 |
