2OZO

Autoinhibited intact human ZAP-70

Summary for 2OZO

Entry DOI	10.2210/pdb2ozo/pdb
Descriptor	Tyrosine-protein kinase ZAP-70, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	inactive zap-70, tandem sh2, autoinhibition, itam, hydrogen bonding network, tcr signaling, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): P43403
Total number of polymer chains	1
Total formula weight	69879.16
Authors	Deindl, S.,Kadlecek, T.A.,Brdicka, T.,Cao, X.,Weiss, A.,Kuriyan, J. (deposition date: 2007-02-26, release date: 2007-05-22, Last modification date: 2024-02-21)
Primary citation	Deindl, S.,Kadlecek, T.A.,Brdicka, T.,Cao, X.,Weiss, A.,Kuriyan, J. Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70. Cell(Cambridge,Mass.), 129:735-746, 2007 Cited by PubMed: 17512407 DOI: 10.1016/j.cell.2007.03.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation