2OZO
Autoinhibited intact human ZAP-70
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001772 | cellular_component | immunological synapse |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002684 | biological_process | positive regulation of immune system process |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006955 | biological_process | immune response |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0018108 | biological_process | peptidyl-tyrosine phosphorylation |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030217 | biological_process | T cell differentiation |
| A | 0035401 | molecular_function | histone H3Y41 kinase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042101 | cellular_component | T cell receptor complex |
| A | 0042110 | biological_process | T cell activation |
| A | 0042113 | biological_process | B cell activation |
| A | 0043366 | biological_process | beta selection |
| A | 0045059 | biological_process | positive thymic T cell selection |
| A | 0045060 | biological_process | negative thymic T cell selection |
| A | 0045061 | biological_process | thymic T cell selection |
| A | 0045087 | biological_process | innate immune response |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045582 | biological_process | positive regulation of T cell differentiation |
| A | 0046632 | biological_process | alpha-beta T cell differentiation |
| A | 0046638 | biological_process | positive regulation of alpha-beta T cell differentiation |
| A | 0046641 | biological_process | positive regulation of alpha-beta T cell proliferation |
| A | 0050776 | biological_process | regulation of immune response |
| A | 0050850 | biological_process | positive regulation of calcium-mediated signaling |
| A | 0050852 | biological_process | T cell receptor signaling pathway |
| A | 0070489 | biological_process | T cell aggregation |
| A | 0072678 | biological_process | T cell migration |
| A | 0140801 | molecular_function | histone H2AXY142 kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 614 |
| Chain | Residue |
| A | ASN466 |
| A | ASP479 |
| A | ANP615 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ANP A 615 |
| Chain | Residue |
| A | ALA367 |
| A | LYS369 |
| A | GLU415 |
| A | ALA417 |
| A | PRO421 |
| A | ARG465 |
| A | ASN466 |
| A | LEU468 |
| A | ASP479 |
| A | MG614 |
| A | HOH655 |
| A | HOH671 |
| A | LEU344 |
| A | CYS346 |
| A | GLY347 |
| A | ASN348 |
| A | PHE349 |
| A | VAL352 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 26 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGCGNFGSVRqGvyrmrkkqid........VAIK |
| Chain | Residue | Details |
| A | LEU344-LYS369 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:15292186, ECO:0000269|PubMed:17512407 |
| Chain | Residue | Details |
| A | ASN461 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY345 | |
| A | LYS369 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR248 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15144186 |
| Chain | Residue | Details |
| A | SER289 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR292 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by LCK => ECO:0000269|PubMed:10037717 |
| Chain | Residue | Details |
| A | PHE315 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10037717 |
| Chain | Residue | Details |
| A | PHE319 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:7781602 |
| Chain | Residue | Details |
| A | TYR492 | |
| A | TYR493 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS603 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26903241 |
| Chain | Residue | Details |
| A | LYS544 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ARG465 | |
| A | ASN461 |
