2OZO
Autoinhibited intact human ZAP-70
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase ZAP-70 | polymer | 613 | 69348.7 | 1 | UniProt (P43403) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | 70 kDa zeta-associated protein, Syk-related tyrosine kinase |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D (A) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A: 1 - 606 (UniProt: P43403)
| PDB | External Database | Details |
|---|---|---|
| Phe 315 | Tyr 315 | engineered mutation |
| Phe 319 | Tyr 319 | engineered mutation |
| Asn 461 | Asp 461 | engineered mutation |
| Gly 607 | - | cloning artifact |
| Ser 608 | - | cloning artifact |
| Ala 609 | - | cloning artifact |
| Leu 610 | - | cloning artifact |
| Glu 611 | - | cloning artifact |
| Val 612 | - | cloning artifact |
| Ala 613 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 69348.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 530.5 | |
| All* | Total formula weight | 69879.2 |
