2DRD
Crystal structure of a multidrug transporter reveal a functionally rotating mechanism
Summary for 2DRD
Entry DOI | 10.2210/pdb2drd/pdb |
Related | 2DHH 2DR6 |
Descriptor | ACRB, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE (2 entities in total) |
Functional Keywords | membrane transporter, membrane protein, multidrug efflux, drug resistance, transporter, exporter, antiporter |
Biological source | Escherichia coli |
Cellular location | Cell inner membrane; Multi-pass membrane protein: P31224 |
Total number of polymer chains | 3 |
Total formula weight | 343110.70 |
Authors | Murakami, S.,Nakashima, R.,Yamashita, E.,Matsumoto, T. (deposition date: 2006-06-08, release date: 2006-08-22, Last modification date: 2024-03-13) |
Primary citation | Murakami, S.,Nakashima, R.,Yamashita, E.,Matsumoto, T.,Yamaguchi, A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism Nature, 443:173-179, 2006 Cited by PubMed: 16915237DOI: 10.1038/nature05076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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