1RV1
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Summary for 1RV1
Entry DOI | 10.2210/pdb1rv1/pdb |
Related | 1YCR |
Descriptor | Ubiquitin-protein ligase E3 Mdm2, CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE (3 entities in total) |
Functional Keywords | mdm2, p53, protein-protein interaction, ligase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 3 |
Total formula weight | 33614.70 |
Authors | Lukacs, C.,Kammlott, U.,Graves, B. (deposition date: 2003-12-12, release date: 2004-01-20, Last modification date: 2023-08-23) |
Primary citation | Vassilev, L.T.,Vu, B.T.,Graves, B.,Carvajal, D.,Podlaski, F.,Filipovic, Z.,Kong, N.,Kammlott, U.,Lukacs, C.,Klein, C.,Fotouhi, N.,Liu, E.A. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science, 303:844-848, 2004 Cited by PubMed: 14704432DOI: 10.1126/science.1092472 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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