9ZFO

Cryo-EM Structure of Human STAT2-USP18-ISG15 Complex

Summary for 9ZFO

Entry DOI	10.2210/pdb9zfo/pdb
EMDB information	74146
Descriptor	Ubl carboxyl-terminal hydrolase 18, Signal transducer and activator of transcription 2, Ubiquitin-like protein ISG15 (3 entities in total)
Functional Keywords	deubiquitinating enzyme, isgylation, transcription factor, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	140375.18
Authors	Huynh, K.W.,Yamaguchi, M. (deposition date: 2025-12-01, release date: 2026-03-18)
Primary citation	Huynh, K.W.,Plumb, R.,Healy, D.R.,Jove, V.,Ralph, E.C.,Lee, C.W.,Wheeler, H.,Levine, K.,Huang, Z.,Fennell, K.,Corpina, R.A.,Craig, T.,Wes, P.D.,Loria, P.M.,Schenone, M.,Han, S.,Wang, F.,Wu, H.,Yamaguchi, M. Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex Biorxiv, 2026 Cited by DOI: 10.64898/2026.02.12.705587 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.05 Å)

Structure validation