9ZFO
Cryo-EM Structure of Human STAT2-USP18-ISG15 Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0002682 | biological_process | regulation of immune system process |
| I | 0005178 | molecular_function | integrin binding |
| I | 0005515 | molecular_function | protein binding |
| I | 0005576 | cellular_component | extracellular region |
| I | 0005634 | cellular_component | nucleus |
| I | 0005654 | cellular_component | nucleoplasm |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0007229 | biological_process | integrin-mediated signaling pathway |
| I | 0009615 | biological_process | response to virus |
| I | 0019941 | biological_process | modification-dependent protein catabolic process |
| I | 0022626 | cellular_component | cytosolic ribosome |
| I | 0030501 | biological_process | positive regulation of bone mineralization |
| I | 0031386 | molecular_function | protein tag activity |
| I | 0031397 | biological_process | negative regulation of protein ubiquitination |
| I | 0032020 | biological_process | ISG15-protein conjugation |
| I | 0032461 | biological_process | positive regulation of protein oligomerization |
| I | 0032649 | biological_process | regulation of type II interferon production |
| I | 0032728 | biological_process | positive regulation of interferon-beta production |
| I | 0032729 | biological_process | positive regulation of type II interferon production |
| I | 0032733 | biological_process | positive regulation of interleukin-10 production |
| I | 0034340 | biological_process | response to type I interferon |
| I | 0042742 | biological_process | defense response to bacterium |
| I | 0045071 | biological_process | negative regulation of viral genome replication |
| I | 0045087 | biological_process | innate immune response |
| I | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| I | 0051240 | biological_process | positive regulation of multicellular organismal process |
| I | 0051607 | biological_process | defense response to virus |
| I | 0060339 | biological_process | negative regulation of type I interferon-mediated signaling pathway |
| I | 0070585 | biological_process | protein localization to mitochondrion |
| U | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| U | 0005515 | molecular_function | protein binding |
| U | 0005634 | cellular_component | nucleus |
| U | 0005737 | cellular_component | cytoplasm |
| U | 0005829 | cellular_component | cytosol |
| U | 0016579 | biological_process | protein deubiquitination |
| U | 0019785 | molecular_function | ISG15-specific peptidase activity |
| U | 0035634 | biological_process | response to stilbenoid |
| U | 0050727 | biological_process | regulation of inflammatory response |
| U | 0051707 | biological_process | response to other organism |
| U | 0060090 | molecular_function | molecular adaptor activity |
| U | 0060339 | biological_process | negative regulation of type I interferon-mediated signaling pathway |
| U | 0110076 | biological_process | negative regulation of ferroptosis |
| U | 0140374 | biological_process | antiviral innate immune response |
| U | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLhniGQtCCLNSlIQ |
| Chain | Residue | Details |
| U | GLY56-GLN71 |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YeLfAViaHvGmads..GHY |
| Chain | Residue | Details |
| U | TYR302-TYR319 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 61 |
| Details | Region: {"description":"Mediates interaction with STAT2","evidences":[{"source":"PubMed","id":"28165510","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway","evidences":[{"source":"PubMed","id":"28165510","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23139419","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Region: {"description":"Involved in the ligation of specific target proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LRLRGG"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
