9Y70

Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed I

Summary for 9Y70

Entry DOI	10.2210/pdb9y70/pdb
EMDB information	72637
Descriptor	Mucolipin-2, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (2 entities in total)
Functional Keywords	cation channel, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	263532.10
Authors	Park, S.,Yang, J. (deposition date: 2025-09-09, release date: 2026-09-16)
Primary citation	Park, S.,Yang, J. Conformational landscape of synergistic activation of mouse TRPML2 channel To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.16 Å)

Structure validation