9Y70
Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed I
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 404 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 64 |
| Details | Region: {"description":"Extracellular/lumenal pore loop","evidences":[{"source":"UniProtKB","id":"Q9GZU1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"F6RG56","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
