9SH5

The cryo-EM structure of human Tissue Nonspecific Alkaline Phosphatase (hTNAP) in complex with MLS-0038949

This is a non-PDB format compatible entry.

Summary for 9SH5

• Entry DOI: 10.2210/pdb9sh5/pdb
• EMDB information: 54888
• Descriptor: Alkaline phosphatase, tissue-nonspecific isozyme, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: inhibitor, alkaline phosphatase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 119952.80

Authors

Imam, I.,Coureux, P.D.,Ballut, L. (deposition date: 2025-08-25, release date: 2025-11-05)

• Primary citation: Drevet Mulard, E.,Imam, I.,Coureux, P.D.,Briolay, A.,Bessueille, L.,Tarby, A.,Balayssac, S.,Narisawa, S.,Lecornu, F.,Gilard, V.,Violot, S.,Millan, J.L.,Rautureau, G.J.P.,Ballut, L.,Magne, D.; TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.27 Å)