9R3S

pro-TGF-beta1 in complex with the third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1

Summary for 9R3S

• Entry DOI: 10.2210/pdb9r3s/pdb
• Related: 1KSQ 5VQP
• EMDB information: 53558
• Descriptor: Transforming growth factor beta-1 proprotein, Latent-transforming growth factor beta-binding protein 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: latent transforming growth factor tgf-beta1, ltbp1, mechanobiology, extracellular matrix protein, disulphide, cytokine, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 135103.60

Authors

Biggin, G.,Snee, M.,Godwin, A.,Roseman, A.,Baldock, C. (deposition date: 2025-05-06, release date: 2026-07-22)

• Primary citation: Biggin, G.; Structural basis for the contribution of latent TGF beta binding protein to TGF beta latency and activation; Nat Commun, 2026

Experimental method

ELECTRON MICROSCOPY (3.06 Å)