9R3S
pro-TGF-beta1 in complex with the third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Transforming growth factor beta-1 proprotein | polymer | 369 | 42320.2 | 2 | UniProt (P01137) Pfam (PF00688) Pfam (PF00019) | Homo sapiens (human) | |
| 2 | C (C) | Latent-transforming growth factor beta-binding protein 1 | polymer | 435 | 47603.6 | 1 | UniProt (Q14766) Pfam (PF00683) Pfam (PF07645) | Homo sapiens (human) | LTBP-1,Transforming growth factor beta-1-binding protein 1,TGF-beta1-BP-1 |
| 3 | D, F (D, F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E, G (E, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 5 | H (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) | |||
| 6 | I, J, K (B, A, C) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
B, A: 30 - 390 (UniProt: P01137)
C: 1335 - 1720 (UniProt: Q14766)
| PDB | External Database | Details |
|---|---|---|
| Asp 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Lys 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Lys 29 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 1331 | - | expression tag |
| Pro 1332 | - | expression tag |
| Leu 1333 | - | expression tag |
| Ala 1334 | - | expression tag |
| Thr 1721 | - | expression tag |
| Gly 1722 | - | expression tag |
| Gly 1723 | - | expression tag |
| Gly 1724 | - | expression tag |
| Gly 1725 | - | expression tag |
| Ser 1726 | - | expression tag |
| Gly 1727 | - | expression tag |
| Gly 1728 | - | expression tag |
| Gly 1729 | - | expression tag |
| Gly 1730 | - | expression tag |
| Ser 1731 | - | expression tag |
| Gly 1732 | - | expression tag |
| Gly 1733 | - | expression tag |
| Gly 1734 | - | expression tag |
| Gly 1735 | - | expression tag |
| Ser 1736 | - | expression tag |
| Ala 1737 | - | expression tag |
| Trp 1738 | - | expression tag |
| Ser 1739 | - | expression tag |
| His 1740 | - | expression tag |
| Pro 1741 | - | expression tag |
| Gln 1742 | - | expression tag |
| Phe 1743 | - | expression tag |
| Glu 1744 | - | expression tag |
| Lys 1745 | - | expression tag |
| Gly 1746 | - | expression tag |
| Gly 1747 | - | expression tag |
| Gly 1748 | - | expression tag |
| Ser 1749 | - | expression tag |
| Gly 1750 | - | expression tag |
| Gly 1751 | - | expression tag |
| Gly 1752 | - | expression tag |
| Ser 1753 | - | expression tag |
| Gly 1754 | - | expression tag |
| Gly 1755 | - | expression tag |
| Ser 1756 | - | expression tag |
| Ala 1757 | - | expression tag |
| Trp 1758 | - | expression tag |
| Ser 1759 | - | expression tag |
| His 1760 | - | expression tag |
| Pro 1761 | - | expression tag |
| Gln 1762 | - | expression tag |
| Phe 1763 | - | expression tag |
| Glu 1764 | - | expression tag |
| Lys 1765 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 132243.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2638.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 135103.6 |
