9QFC

Tankyrase 2 ARC4 in complex with a pyrrolone-based inhibitor

This is a non-PDB format compatible entry.

Summary for 9QFC

• Entry DOI: 10.2210/pdb9qfc/pdb
• Descriptor: Poly [ADP-ribose] polymerase tankyrase-2, (2~{S})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one, (2~{R})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one, ... (5 entities in total)
• Functional Keywords: inhibitor, transferase, tankyrase 2, tnks2, parp5, arc4
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 37272.21

Authors

Bosetti, C.,Paakkonen, J.,Lehtio, L. (deposition date: 2025-03-11, release date: 2026-01-14)

• Primary citation: Bosetti, C.,Paakkonen, J.,Lehtio, L.; Tankyrase 2 ARC4 in complex with a pyrrolone-based inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)