9QFC
Tankyrase 2 ARC4 in complex with a pyrrolone-based inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 162 | 17652.0 | 2 | UniProt (Q9H2K2) Pfam (PF12796) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 2 | C, F (A, B) | (2~{S})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one | non-polymer | 465.5 | 2 | Chemie (A1I5S) | |||
| 3 | D, G (A, B) | (2~{R})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one | non-polymer | 465.5 | 2 | Chemie (A1I6W) | |||
| 4 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A, B: 487 - 647 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 486 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35303.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1968.3 | |
| All* | Total formula weight | 37272.2 |
