9QCD

Micro-ED structure of the NSH2-CSH2 tandem domain of SHP2 in complex with the bis-phosphorylated pY627-pY659-Gab1 (613-694) peptide

Summary for 9QCD

Entry DOI	10.2210/pdb9qcd/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11, GRB2-associated-binding protein 1 (2 entities in total)
Functional Keywords	sh2-domain, phosphatase, ptpn11, phospho-tyrosine, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	32840.52
Authors	Machner, L.,Shaikhqasem, A.,Hamdi, F.,Breithaupt, C.,Parthier, C.,Kyrilis, F.L.,Kastritis, P.L.,Feller, S.M.,Stubbs, M.T. (deposition date: 2025-03-04, release date: 2025-12-31)
Primary citation	Machner, L.,Shaikhqasem, A.,Gruber, T.,Hamdi, F.,Breithaupt, C.,Kniest, J.,Wiebe, F.,Lewitzky, M.,Parthier, C.,Kyrilis, F.L.,Balbach, J.,Kastritis, P.L.,Feller, S.M.,Stubbs, M.T. Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1 Structure, 2025 Cited by DOI: 10.1016/j.str.2025.11.018 PDB entries with the same primary citation
Experimental method	ELECTRON CRYSTALLOGRAPHY (3.2 Å)

Structure validation