9QCD

Micro-ED structure of the NSH2-CSH2 tandem domain of SHP2 in complex with the bis-phosphorylated pY627-pY659-Gab1 (613-694) peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Tyrosine-protein phosphatase non-receptor type 11	polymer	223	25133.2	1	UniProt (Q06124) Pfam (PF00017)	Homo sapiens (human)	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3
2	B (C)	GRB2-associated-binding protein 1	polymer	69	7707.3	1	UniProt (Q13480)	Homo sapiens (human)	GRB2-associated binder 1,Growth factor receptor bound protein 2-associated protein 1

Sequence modifications

B: 1 - 222 (UniProt: Q06124)

PDB	External Database	Details
Ser 0	-	expression tag

C: 617 - 683 (UniProt: Q13480)

PDB	External Database	Details
Gly 615	-	expression tag
Pro 616	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32840.5
All*	Total formula weight	32840.5

*Water molecules are not included.