9Q8V

Cryo-EM structure of the NLRP3 decamer bound to the inhibitor BAL-1516

This is a non-PDB format compatible entry.

Summary for 9Q8V

• Entry DOI: 10.2210/pdb9q8v/pdb
• Related: 9IHN
• EMDB information: 52908
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: nlrp3, nod-like receptor, bal compound, immune system, inflammasome
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 1192105.79

Authors

Torp, J.,Wilhelmsen, K.,Hartman, G.,Hagelueken, G.,Geyer, M. (deposition date: 2025-02-25, release date: 2026-09-09)

• Primary citation: Torp, J.,Geyer, M.; Inhibition of NLRP3 by a CNS-penetrating indazole scaffold; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.06 Å)