9Q8V

Cryo-EM structure of the NLRP3 decamer bound to the inhibitor BAL-1516

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	NACHT, LRR and PYD domains-containing protein 3	polymer	1036	118323.5	10	UniProt (Q96P20)	Homo sapiens (human)	Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1
2	CA, FA, IA, K, LA... (G, H, I, A, J...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	10	Chemie (ADP)
3	AA, DA, GA, JA, L... (F, G, H, I, A...)	MAGNESIUM ION	non-polymer		24.3	10	Chemie (MG) PubChem (888)
4	BA, EA, HA, KA, M... (F, G, H, I, A...)	3-ethoxy-~{N}-methyl-~{N}-[(1~{R})-1-(4-methyl-1~{H}-pyrazolo[4,3-c]pyridin-7-yl)ethyl]-4-(4-methyl-1,3-thiazol-2-yl)benzamide	non-polymer		435.5	10	Chemie (A1I4G)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	1183235.3
Non-Polymers*	Number of molecules	30
	Total formula weight	8870.5
All*	Total formula weight	1192105.8

*Water molecules are not included.