9IHN

Cryo-EM structure of NLRP3 bound to the inhibitor BAL-1516 at 3.06 Ang resolution

This is a non-PDB format compatible entry.

Summary for 9IHN

• Entry DOI: 10.2210/pdb9ihn/pdb
• EMDB information: 52874
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: nlrp3, nod-like receptor, bal compound, inhibitor, inflammasome, bal-1516, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 119210.58

Authors

Torp, J.,Wilhelmsen, K.,Hartman, G.,Hagelueken, G.,Geyer, M. (deposition date: 2025-02-21, release date: 2026-09-02)

• Primary citation: Torp, J.,Geyer, M.; Inhibition of NLRP3 by a CNS-penetrating indazole scaffold; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.06 Å)