9PQ1

The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors

This is a non-PDB format compatible entry.

Summary for 9PQ1

• Entry DOI: 10.2210/pdb9pq1/pdb
• Related: 5I25
• Descriptor: Coagulation factor XI, Kininogen-1 light chain, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: coagulation fxi, high molecular weight kininogen, hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 73093.10

Authors

Hruza, A.,Ogawa, A. (deposition date: 2025-07-22, release date: 2026-07-29)

• Primary citation: Ellsworth, K.,Nizner, P.,Ogawa, A.,Hruza, A.,Wei, L.,Yang, D.,Lombardo, M.,Sonatore, L.,Barbieri, C.M.,Wickham, A.,Chamberlin, C.,Nickbarg, E.,Richards, M.,Sauvegnat, B.,Ziebell, M.,Ho, T.,Ali, A.,Hicks, J.,Sheth, P.,Tata, J.; The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.218 Å)