9PJ1

Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of FKBP12, Rapamycin, and the FRB domain of mTOR

Summary for 9PJ1

• Entry DOI: 10.2210/pdb9pj1/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, Heavy chain, ... (6 entities in total)
• Functional Keywords: antibody, mtor, rapamycin, sensor, immune system, immune system-transferase-isomerase complex, immune system/transferase/isomerase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 70961.72

Authors

O'Leary, K.M.,Slezak, T.,Kossiakoff, A.A. (deposition date: 2025-07-11, release date: 2026-06-17)

• Primary citation: O'Leary, K.M.,Slezak, T.,Kossiakoff, A.A.; Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of FKBP12, Rapamycin, and the FRB domain of mTOR; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)