9PJ1

Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of FKBP12, Rapamycin, and the FRB domain of mTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003007	biological_process	heart morphogenesis
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005160	molecular_function	transforming growth factor beta receptor binding
C	0005246	molecular_function	calcium channel regulator activity
C	0005515	molecular_function	protein binding
C	0005527	molecular_function	macrolide binding
C	0005528	molecular_function	FK506 binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006458	biological_process	'de novo' protein folding
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0014802	cellular_component	terminal cisterna
C	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0030018	cellular_component	Z disc
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030547	molecular_function	signaling receptor inhibitor activity
C	0032880	biological_process	regulation of protein localization
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034713	molecular_function	type I transforming growth factor beta receptor binding
C	0042026	biological_process	protein refolding
C	0042110	biological_process	T cell activation
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044325	molecular_function	transmembrane transporter binding
C	0050776	biological_process	regulation of immune response
C	0051604	biological_process	protein maturation
C	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
C	0060347	biological_process	heart trabecula formation
C	0070411	molecular_function	I-SMAD binding
C	0070697	molecular_function	activin receptor binding
C	0097435	biological_process	supramolecular fiber organization
C	0098562	cellular_component	cytoplasmic side of membrane
C	1902991	biological_process	regulation of amyloid precursor protein catabolic process
C	1990000	biological_process	amyloid fibril formation
C	1990425	cellular_component	ryanodine receptor complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR207-HIS213
L	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P26883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37979583","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 362

Chain

Residue

Details

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