9PJ1
Crystal structure of a synthetic Fab (4R) in complex with the ternary assembly of FKBP12, Rapamycin, and the FRB domain of mTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 108 | 11923.6 | 1 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
| 2 | B (D) | Serine/threonine-protein kinase mTOR | polymer | 92 | 11161.7 | 1 | UniProt (P42345) Pfam (PF08771) | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1,Tyrosine-protein kinase mTOR |
| 3 | C (H) | Heavy chain | polymer | 227 | 23965.7 | 1 | Homo sapiens | ||
| 4 | D (L) | Light chain | polymer | 213 | 22996.5 | 1 | Homo sapiens | ||
| 5 | E (C) | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 1 | Chemie (RAP) PubChem (5284616) | |||
| 6 | F, G, H, I (C, D, H, L) | water | water | 18.0 | 501 | Chemie (HOH) |
Sequence modifications
C: 2 - 108 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70047.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 914.2 | |
| All* | Total formula weight | 70961.7 |
