9NXS

Crystal structure of the post-reactive state of porcine OAS1 in complex with dsRNA and products 25A2 and PPi bound to the catalytic center.

Summary for 9NXS

• Entry DOI: 10.2210/pdb9nxs/pdb
• Related: 4RWN 4RWO 4RWP 4RWQ
• Descriptor: 2'-5'-oligoadenylate synthase 1, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), ... (9 entities in total)
• Functional Keywords: innate immunity, bimetallic nucleotidyltransferases, transferase, transferase-rna complex, transferase/rna
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 3
• Total formula weight: 54848.45

Authors

Kats, P.,Zhou, X.,Wiebe, J.,Zeymer, O.,Baruch, P.,Taft, M.H.,Reinke, P.Y.A.,Guenther, S.,Meents, A.,Hartmann, R.,Manstein, D.J.,Fedorov, R. (deposition date: 2025-03-26, release date: 2026-04-08)

• Primary citation: Kats, P.,Zhou, X.,Wiebe, J.,Zeymer, O.,Baruch, P.,Taft, M.H.,Reinke, P.Y.A.,Guenther, S.,Meents, A.,Hartmann, R.,Manstein, D.J.,Fedorov, R.; The Enzymatic Mechanism of OAS: How Metal Ions and Quantum Effects Help Activate Innate Immunity; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)