9N8Z

Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649, class 2

This is a non-PDB format compatible entry.

Summary for 9N8Z

• Entry DOI: 10.2210/pdb9n8z/pdb
• Related: 9N8Y
• EMDB information: 49154
• Descriptor: Metabotropic glutamate receptor 8, (2S)-2-amino-4-phosphonobutanoic acid, (3P,8S)-3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (3 entities in total)
• Functional Keywords: gpcr, metabotropic glutamate receptor, membrane protein, synaptic protein, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 202842.83

Authors

Marx, D.C.,Levitz, J.T. (deposition date: 2025-02-10, release date: 2026-09-09)

• Primary citation: Marx, D.C.,Gonzalez-Hernandez, A.J.,Huynh, K.,Strauss, A.,Rico, C.,Siepe, D.,Gallo, P.N.,Lee, J.,Sharghi, S.,Arefin, A.,Broichhagen, J.,Eliezer, D.,Kalocsay, M.,Khelashvilli, G.,Levitz, J.; Structural Diversity of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling; To Be Published, To Be Published:-,

Experimental method

ELECTRON MICROSCOPY (2.97 Å)