9N8Z
Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649, class 2
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 8 | polymer | 901 | 100881.0 | 2 | UniProt (O00222) | Homo sapiens (human) | mGluR8 |
| 2 | C, F (A, B) | (2S)-2-amino-4-phosphonobutanoic acid | non-polymer | 183.1 | 2 | Chemie (E7P) PubChem (179394) | |||
| 3 | D, E (A, B) | (3P,8S)-3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine | non-polymer | 357.3 | 2 | Chemie (A1BWG) |
Sequence modifications
A, B: 34 - 908 (UniProt: O00222)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | initiating methionine |
| Lys 9 | - | expression tag |
| Thr 10 | - | expression tag |
| Ile 11 | - | expression tag |
| Ile 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Tyr 16 | - | expression tag |
| Ile 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Cys 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Val 21 | - | expression tag |
| Phe 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Tyr 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Asp 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Ala 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 201762.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1080.8 | |
| All* | Total formula weight | 202842.8 |
