9N8Y

Cryo EM Structure of Full Length mGluR8 Bound to Agonist L-AP4 and PAM VU6005649

Summary for 9N8Y

Entry DOI	10.2210/pdb9n8y/pdb
EMDB information	49153
Descriptor	Metabotropic glutamate receptor 8, (2S)-2-amino-4-phosphonobutanoic acid, (3P,8S)-3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (3 entities in total)
Functional Keywords	gpcr, metabotropic glutamate receptor, membrane protein, synaptic protein, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	188987.29
Authors	Marx, D.C.,Levitz, J.T. (deposition date: 2025-02-10, release date: 2026-09-09)
Primary citation	Marx, D.C.,Gonzalex-Hernandez, A.J.,Huynh, K.,Strauss, A.,Rico, C.,Siepe, D.,Gallo, P.N.,Lee, J.,Sharghi, S.,Arefin, A.,Broichhagen, J.,Eliezer, D.,Kalocsay, M.,Khelashvilli, G.,Levitz, J. Structural Diversity of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling To Be Published, To Be Published:-,
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation