9M1Z

Crystal Structure of MAP2K6 complexed with 5Z-7-oxozeaenol

Summary for 9M1Z

• Entry DOI: 10.2210/pdb9m1z/pdb
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 6, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione (3 entities in total)
• Functional Keywords: mitogen-activated protein kinase kinase 6, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 154926.28

Authors

Yumura, S.,Kinoshita, T. (deposition date: 2025-02-26, release date: 2026-03-04)

• Primary citation: Yumura, S.,Kinoshita, T.; The discrepancies in amino acid sequence of the phosphate-binding loop lead to distinctive binding modes of a covalent inhibitor for MAP2K1 and MAP2K6: Structural insights for producing selective inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (3 Å)