Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9M1Z

Crystal Structure of MAP2K6 complexed with 5Z-7-oxozeaenol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0001649	biological_process	osteoblast differentiation
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004708	molecular_function	MAP kinase kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0007165	biological_process	signal transduction
A	0019901	molecular_function	protein kinase binding
A	0031098	biological_process	stress-activated protein kinase signaling cascade
A	0035872	biological_process	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
A	0038066	biological_process	p38MAPK cascade
A	0042770	biological_process	signal transduction in response to DNA damage
A	0051403	biological_process	stress-activated MAPK cascade
A	0051726	biological_process	regulation of cell cycle
A	0060348	biological_process	bone development
A	0090398	biological_process	cellular senescence
A	0106310	molecular_function	protein serine kinase activity
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1902531	biological_process	regulation of intracellular signal transduction
B	0000165	biological_process	MAPK cascade
B	0001649	biological_process	osteoblast differentiation
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004708	molecular_function	MAP kinase kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0007165	biological_process	signal transduction
B	0019901	molecular_function	protein kinase binding
B	0031098	biological_process	stress-activated protein kinase signaling cascade
B	0035872	biological_process	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
B	0038066	biological_process	p38MAPK cascade
B	0042770	biological_process	signal transduction in response to DNA damage
B	0051403	biological_process	stress-activated MAPK cascade
B	0051726	biological_process	regulation of cell cycle
B	0060348	biological_process	bone development
B	0090398	biological_process	cellular senescence
B	0106310	molecular_function	protein serine kinase activity
B	0120163	biological_process	negative regulation of cold-induced thermogenesis
B	1901796	biological_process	regulation of signal transduction by p53 class mediator
B	1902531	biological_process	regulation of intracellular signal transduction
C	0000165	biological_process	MAPK cascade
C	0001649	biological_process	osteoblast differentiation
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004708	molecular_function	MAP kinase kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0007165	biological_process	signal transduction
C	0019901	molecular_function	protein kinase binding
C	0031098	biological_process	stress-activated protein kinase signaling cascade
C	0035872	biological_process	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
C	0038066	biological_process	p38MAPK cascade
C	0042770	biological_process	signal transduction in response to DNA damage
C	0051403	biological_process	stress-activated MAPK cascade
C	0051726	biological_process	regulation of cell cycle
C	0060348	biological_process	bone development
C	0090398	biological_process	cellular senescence
C	0106310	molecular_function	protein serine kinase activity
C	0120163	biological_process	negative regulation of cold-induced thermogenesis
C	1901796	biological_process	regulation of signal transduction by p53 class mediator
C	1902531	biological_process	regulation of intracellular signal transduction
D	0000165	biological_process	MAPK cascade
D	0001649	biological_process	osteoblast differentiation
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004708	molecular_function	MAP kinase kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0007165	biological_process	signal transduction
D	0019901	molecular_function	protein kinase binding
D	0031098	biological_process	stress-activated protein kinase signaling cascade
D	0035872	biological_process	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
D	0038066	biological_process	p38MAPK cascade
D	0042770	biological_process	signal transduction in response to DNA damage
D	0051403	biological_process	stress-activated MAPK cascade
D	0051726	biological_process	regulation of cell cycle
D	0060348	biological_process	bone development
D	0090398	biological_process	cellular senescence
D	0106310	molecular_function	protein serine kinase activity
D	0120163	biological_process	negative regulation of cold-induced thermogenesis
D	1901796	biological_process	regulation of signal transduction by p53 class mediator
D	1902531	biological_process	regulation of intracellular signal transduction

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGAYGVVEkMrhvpsgqi..........MAVK

Chain	Residue	Details
D	LEU59-LYS82

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNVLI

Chain	Residue	Details
D	VAL175-ILE187

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	69
Details	Region: {"description":"DVD domain"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAP3K; alternate","evidences":[{"source":"PubMed","id":"16728640","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24936062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)