9L6S

double-mutant (K217A & K218A) Vitamin K-dependent gamma-carboxylase in complex with coagulation factors X and vitamin K

This is a non-PDB format compatible entry.

Summary for 9L6S

• Entry DOI: 10.2210/pdb9l6s/pdb
• EMDB information: 62864
• Descriptor: Coagulation factor X, Vitamin K-dependent gamma-carboxylase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 146520.28

Authors

Hang, J.,Chen, D.D.,Zhong, Q.H. (deposition date: 2024-12-25, release date: 2025-10-08, Last modification date: 2026-04-22)

• Primary citation: Zhong, Q.,Chen, D.,Xu, J.,Li, Y.,Yuan, W.,Meng, Y.,Wen, Q.,Ye, Q.,Wang, G.,Pan, K.,Song, C.,Tao, L.,Qiao, J.,Hang, J.; Molecular basis of vitamin K-dependent protein gamma-glutamyl carboxylation.; Cell Res., 35:917-920, 2025; PubMed: 41016932; DOI: 10.1038/s41422-025-01185-6

Experimental method

ELECTRON MICROSCOPY (2.58 Å)