Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9L6S

double-mutant (K217A & K218A) Vitamin K-dependent gamma-carboxylase in complex with coagulation factors X and vitamin K

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0007596	biological_process	blood coagulation
A	0008289	molecular_function	lipid binding
A	0008488	molecular_function	gamma-glutamyl carboxylase activity
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0017187	biological_process	peptidyl-glutamic acid carboxylation
A	0019842	molecular_function	vitamin binding
A	0036211	biological_process	protein modification process
A	0042373	biological_process	vitamin K metabolic process
A	0046929	biological_process	negative regulation of neurotransmitter secretion
A	0051604	biological_process	protein maturation
A	1903011	biological_process	negative regulation of bone development
A	2000225	biological_process	negative regulation of testosterone biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDglgeYtCtC

Chain	Residue	Details
C	CYS101-CYS112

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEtCsyeearEvfedsdktne.FW

Chain	Residue	Details
C	GLU56-TRP81

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CtCleGfeGKnC

Chain	Residue	Details
C	CYS110-CYS121

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
C	LEU272-CYS277

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV

Chain	Residue	Details
C	ASP413-VAL424

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CtCleGFegkn....C

Chain	Residue	Details
C	CYS110-CYS121
C	CYS149-CYS164

site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCetsp..........Cqnqgk..CkDglgeYtC

Chain	Residue	Details
C	ASP86-CYS110

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Propeptide: {"featureId":"PRO_0000027786","evidences":[{"source":"PubMed","id":"6871167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00463","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"6871167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	15
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	82
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	34
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	13
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	11
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	14
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	9
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17073445","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880037","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"39880952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9BUX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)