9L6S

double-mutant (K217A & K218A) Vitamin K-dependent gamma-carboxylase in complex with coagulation factors X and vitamin K

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Coagulation factor X	polymer	488	54802.6	1	UniProt (P00742) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) Pfam (PF00089)	Homo sapiens (human)	Stuart factor,Stuart-Prower factor
2	B (A)	Vitamin K-dependent gamma-carboxylase	polymer	758	87539.4	1	UniProt (P38435) Pfam (PF05090) Pfam (PF22777)	Homo sapiens (human)	Gamma-glutamyl carboxylase,Peptidyl-glutamate 4-carboxylase,Vitamin K gamma glutamyl carboxylase
3	C, E (B, E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	F (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	G (A)	2-methyl-3-[(2~{E},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-diol	non-polymer		446.7	1	Chemie (A1EMC)
7	H, I (A)	(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE	non-polymer		763.1	2	Chemie (6PL)
8	J (A)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)

Sequence modifications

A: 1 - 758 (UniProt: P38435)

PDB	External Database	Details
Ala 217	Lys 217	engineered mutation
Ala 218	Lys 218	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	142342.1
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	5
	Total formula weight	2580.7
All*	Total formula weight	146520.3

*Water molecules are not included.