9KFU

Human FGFR3 in complex with inhibitor F1

This is a non-PDB format compatible entry.

Summary for 9KFU

• Entry DOI: 10.2210/pdb9kfu/pdb
• Descriptor: Fibroblast growth factor receptor 3, (7~{S})-2-azanyl-7-(4-fluorophenyl)-6,7-dihydro-4~{H}-[1,3]thiazolo[4,5-b]pyridin-5-one, SULFATE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35440.53

Authors

Zhang, J.,Song, K.,Li, M.Y. (deposition date: 2024-11-07, release date: 2025-09-03)

• Primary citation: Li, M.,Song, K.,He, J.,Zhao, M.,You, G.,Zhong, J.,Zhao, M.,Li, A.,Chen, Y.,Li, G.,Kong, Y.,Wei, J.,Wang, Z.,Zhou, J.,Yang, H.,Ma, S.,Zhang, H.,Melita, I.L.,Lin, W.,Lu, Y.,Yu, Z.,Lu, X.,Zhao, Y.,Zhang, J.; Electron-density-informed effective and reliable de novo molecular design and optimization with ED2Mol; Nat Mach Intell, 7:1355-1368, 2025; DOI: 10.1038/s42256-025-01095-7

Experimental method

X-RAY DIFFRACTION (1.4 Å)